Association patterns of platinated purine nucleobases in metal-modified pairs and triples

Michael Roitzsch; Irene B. Rother; Michael Willermann; Andrea Erxleben; Burkhard Costisella; Bernhard Lippert

doi:10.1021/ic020403v

Association patterns of platinated purine nucleobases in metal-modified pairs and triples

Michael Roitzsch
, Irene B. Rother
, Michael Willermann
, Andrea Erxleben
, Burkhard Costisella
, Bernhard Lippert

Technische Universität Dortmund

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

27 Citations (Scopus)

Abstract

Blocking of Watson-Crick or Hoogsteen edges in purine nucleobases by a metal entity precludes involvement of these sites in interbase hydrogen bonding, thereby leaving the respective other edge or the sugar edge as potential H bonding sites. In mixed guanine, adenine complexes of trans-a₂Pt^II (a = NH₃ or CH₃NH₂) of composition trans-[(NH₃)₂Pt(9-EtA-N1)(9-MeGH-N7)] (NO₃)₂ (1a), trans-[(NH₃)₂Pt(9-EtA-N1)(9-MeGH-N7)] (CIO₄)₂ (1b), and trans,trans-[(CH₃NH₂)₂ (9-MeGH-N7)Pt(N1-9-MeA-N7)Pt(9-MeGH-N7) (CH₃NH₂)₂] (CIO₄)₄·2H₂O (2) (with 9-EtA = 9-ethyladenine, 9-MeA= 9-methyladenine, 9-MeGH = 9-methylguanine), this aspect is studied. Thus, in 1b pairing of two adenine ligands via Hoogsteen edges and in 2 pairing of two guanine bases via sugar edges is realized. These situations are compared with those found in a series of related complexes.

Original language	English
Pages (from-to)	5946-5953
Number of pages	8
Journal	Inorganic Chemistry
Volume	41
Issue number	23
DOIs	https://doi.org/10.1021/ic020403v
Publication status	Published - 18 Nov 2002
Externally published	Yes

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@article{340ef51c31a6470a8d5d9f5bdd8fdff7,

title = "Association patterns of platinated purine nucleobases in metal-modified pairs and triples",

abstract = "Blocking of Watson-Crick or Hoogsteen edges in purine nucleobases by a metal entity precludes involvement of these sites in interbase hydrogen bonding, thereby leaving the respective other edge or the sugar edge as potential H bonding sites. In mixed guanine, adenine complexes of trans-a2PtII (a = NH3 or CH3NH2) of composition trans-[(NH3)2Pt(9-EtA-N1)(9-MeGH-N7)] (NO3)2 (1a), trans-[(NH3)2Pt(9-EtA-N1)(9-MeGH-N7)] (CIO4)2 (1b), and trans,trans-[(CH3NH2)2 (9-MeGH-N7)Pt(N1-9-MeA-N7)Pt(9-MeGH-N7) (CH3NH2)2] (CIO4)4·2H2O (2) (with 9-EtA = 9-ethyladenine, 9-MeA= 9-methyladenine, 9-MeGH = 9-methylguanine), this aspect is studied. Thus, in 1b pairing of two adenine ligands via Hoogsteen edges and in 2 pairing of two guanine bases via sugar edges is realized. These situations are compared with those found in a series of related complexes.",

author = "Michael Roitzsch and Rother, \{Irene B.\} and Michael Willermann and Andrea Erxleben and Burkhard Costisella and Bernhard Lippert",

year = "2002",

month = nov,

day = "18",

doi = "10.1021/ic020403v",

language = "English",

volume = "41",

pages = "5946--5953",

journal = "Inorganic Chemistry",

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publisher = "American Chemical Society",

number = "23",

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TY - JOUR

T1 - Association patterns of platinated purine nucleobases in metal-modified pairs and triples

AU - Roitzsch, Michael

AU - Rother, Irene B.

AU - Willermann, Michael

AU - Erxleben, Andrea

AU - Costisella, Burkhard

AU - Lippert, Bernhard

PY - 2002/11/18

Y1 - 2002/11/18

N2 - Blocking of Watson-Crick or Hoogsteen edges in purine nucleobases by a metal entity precludes involvement of these sites in interbase hydrogen bonding, thereby leaving the respective other edge or the sugar edge as potential H bonding sites. In mixed guanine, adenine complexes of trans-a2PtII (a = NH3 or CH3NH2) of composition trans-[(NH3)2Pt(9-EtA-N1)(9-MeGH-N7)] (NO3)2 (1a), trans-[(NH3)2Pt(9-EtA-N1)(9-MeGH-N7)] (CIO4)2 (1b), and trans,trans-[(CH3NH2)2 (9-MeGH-N7)Pt(N1-9-MeA-N7)Pt(9-MeGH-N7) (CH3NH2)2] (CIO4)4·2H2O (2) (with 9-EtA = 9-ethyladenine, 9-MeA= 9-methyladenine, 9-MeGH = 9-methylguanine), this aspect is studied. Thus, in 1b pairing of two adenine ligands via Hoogsteen edges and in 2 pairing of two guanine bases via sugar edges is realized. These situations are compared with those found in a series of related complexes.

AB - Blocking of Watson-Crick or Hoogsteen edges in purine nucleobases by a metal entity precludes involvement of these sites in interbase hydrogen bonding, thereby leaving the respective other edge or the sugar edge as potential H bonding sites. In mixed guanine, adenine complexes of trans-a2PtII (a = NH3 or CH3NH2) of composition trans-[(NH3)2Pt(9-EtA-N1)(9-MeGH-N7)] (NO3)2 (1a), trans-[(NH3)2Pt(9-EtA-N1)(9-MeGH-N7)] (CIO4)2 (1b), and trans,trans-[(CH3NH2)2 (9-MeGH-N7)Pt(N1-9-MeA-N7)Pt(9-MeGH-N7) (CH3NH2)2] (CIO4)4·2H2O (2) (with 9-EtA = 9-ethyladenine, 9-MeA= 9-methyladenine, 9-MeGH = 9-methylguanine), this aspect is studied. Thus, in 1b pairing of two adenine ligands via Hoogsteen edges and in 2 pairing of two guanine bases via sugar edges is realized. These situations are compared with those found in a series of related complexes.

UR - https://www.scopus.com/pages/publications/0037131931

U2 - 10.1021/ic020403v

DO - 10.1021/ic020403v

M3 - Article

SN - 0020-1669

VL - 41

SP - 5946

EP - 5953

JO - Inorganic Chemistry

JF - Inorganic Chemistry

IS - 23

ER -

Association patterns of platinated purine nucleobases in metal-modified pairs and triples

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