Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls.

Geraldine Mccarthy

doi:10.1038/88836

Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls.

Geraldine Mccarthy

Medicine

Massachusetts General Hospital
Harvard Medical School
Whitehead Institute
University of Bonn
Cardiff University
State Mental Hospital
University of Pécs Medical School
University of Regensburg
Hadassah Hebrew University Medical Center
The University of Western Australia
Medical University of Sofia

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

60 Citations (Scopus)

Abstract

A genetic association between NOTCH4 and schizophrenia has previously been proposed. Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observation. These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.

Original language	English (Ireland)
Pages (from-to)	126-128
Number of pages	3
Journal	Nature Genetics
Volume	28
Issue number	2
DOIs	https://doi.org/10.1038/88836
Publication status	Published - 1 Jun 2001

Authors (Note for portal: view the doc link for the full list of authors)

Authors
Sklar P, Schwab SG, Williams NM, Daly M, Schaffner S, Maier W, Albus M, Trixler M, Eichhammer P, Lerer B, Hallmayer J, Norton N, Williams H, Zammit S, Cardno AG, Jones S, McCarthy G, Milanova V, Kirov G, O'Donovan MC, Lander ES, Owen MJ, Wildenauer DB

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AB - A genetic association between NOTCH4 and schizophrenia has previously been proposed. Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observation. These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.

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Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls.

Abstract

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