Abstract
The aim of this randomised, observer-blinded, crossover study was to compare the effects of four treatments, administered intravenously to six horses: saline and saline; 10 μg/kg detomidine and 7.5 μg/kg buprenorphine; 20 μg/kg detomidine and 7.5 μg/kg buprenorphine; and 20 μg/kg detomidine and 10 μg/kg buprenorphine. Sedation was subjectively assessed and recorded on a visual analogue scale. Peak sedation and duration of sedation were investigated using a univariate general linear model with post-hoc Tukey tests (P<.05). Increasing the dose of detomidine from 10 to 20 μg/kg increased the degree of sedation when administered with the same dose of buprenorphine (7.5 μg/kg). When administered with 20 μg/kg detomidine, increasing the dose of buprenorphine from 7.5 to 10 μg/kg did not influence the degree of sedation achieved.
| Original language | English |
|---|---|
| Pages (from-to) | 409 |
| Number of pages | 1 |
| Journal | Veterinary Record |
| Volume | 168 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - Apr 2011 |
| Externally published | Yes |