Assessment of the sedative effects of buprenorphine administered with 20 μg/kg detomidine in horses

E. J. Love; P. M. Taylor; J. Murrell; H. R. Whay; A. E. Waterman-Pearson

doi:10.1136/vr.c7315

Assessment of the sedative effects of buprenorphine administered with 20 μg/kg detomidine in horses

E. J. Love, P. M. Taylor, J. Murrell, H. R. Whay, A. E. Waterman-Pearson

University of Bristol

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

10 Citations (Scopus)

Abstract

The aim of this randomised, observer-blinded, crossover study was to compare the effects of four treatments, administered intravenously to six horses: saline and saline; 10 μg/kg detomidine and 7.5 μg/kg buprenorphine; 20 μg/kg detomidine and 7.5 μg/kg buprenorphine; and 20 μg/kg detomidine and 10 μg/kg buprenorphine. Sedation was subjectively assessed and recorded on a visual analogue scale. Peak sedation and duration of sedation were investigated using a univariate general linear model with post-hoc Tukey tests (P<.05). Increasing the dose of detomidine from 10 to 20 μg/kg increased the degree of sedation when administered with the same dose of buprenorphine (7.5 μg/kg). When administered with 20 μg/kg detomidine, increasing the dose of buprenorphine from 7.5 to 10 μg/kg did not influence the degree of sedation achieved.

Original language	English
Pages (from-to)	409
Number of pages	1
Journal	Veterinary Record
Volume	168
Issue number	15
DOIs	https://doi.org/10.1136/vr.c7315
Publication status	Published - Apr 2011
Externally published	Yes

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abstract = "The aim of this randomised, observer-blinded, crossover study was to compare the effects of four treatments, administered intravenously to six horses: saline and saline; 10 μg/kg detomidine and 7.5 μg/kg buprenorphine; 20 μg/kg detomidine and 7.5 μg/kg buprenorphine; and 20 μg/kg detomidine and 10 μg/kg buprenorphine. Sedation was subjectively assessed and recorded on a visual analogue scale. Peak sedation and duration of sedation were investigated using a univariate general linear model with post-hoc Tukey tests (P<.05). Increasing the dose of detomidine from 10 to 20 μg/kg increased the degree of sedation when administered with the same dose of buprenorphine (7.5 μg/kg). When administered with 20 μg/kg detomidine, increasing the dose of buprenorphine from 7.5 to 10 μg/kg did not influence the degree of sedation achieved.",

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AU - Waterman-Pearson, A. E.

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Assessment of the sedative effects of buprenorphine administered with 20 μg/kg detomidine in horses

Abstract

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