TY - JOUR
T1 - Antibodies to periodontal pathogens are associated with coronary plaque remodeling but not with vulnerability or burden
AU - de Boer, Sanneke P.M.
AU - Cheng, Jin M.
AU - Rangé, Hélène
AU - Garcia-Garcia, Hector M.
AU - Heo, Jung Ho
AU - Akkerhuis, K. Martijn
AU - Meilhac, Olivier
AU - Cosler, Guillaume
AU - Pussinen, Pirkko J.
AU - van Geuns, Robert Jan
AU - Serruys, Patrick W.
AU - Boersma, Eric
AU - Kardys, Isabella
N1 - Publisher Copyright:
© 2014 Elsevier Ireland Ltd.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Objective: Previous studies have suggested positive associations between periodontal infection and cardiovascular disease. We aimed to investigate the associations of circulating antibodies against periodontal pathogens with 1-year cardiovascular outcome, as well as the extent of coronary atherosclerosis, plaque vulnerability and lesion remodeling on intravascular ultrasound (IVUS) imaging. Methods: Between 2008 and 2011, radiofrequency IVUS imaging of a non-culprit coronary artery was performed in 581 patients who underwent coronary angiography. Immunoglobulin G (IgG) and A (IgA) against Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Tannerella forsythia and Prevotella intermedia were measured in plasma. Results: None of the antibody levels were associated with coronary plaque burden, radiofreqeuncy-IVUS-derived thin-cap fibroatheroma lesion morphology or 1-year incidence of major adverse cardiac events (MACE), which included all-cause mortality, acute coronary syndrome and unplanned coronary revascularization. IgA against A.actinomycetemcomitans, T.forsythia and P.intermedia were inversely associated with extent of positive lesion remodeling (OR for highest versus lowest tertile 0.55, 95%CI 0.35-0.88, p=0.012; 0.53, 95%CI 0.32-0.87, p=0.012; and 0.64, 95%CI 0.40-1.02, p=0.061, respectively). In diabetic patients specifically, IgG against P.gingivalis tended to be associated with coronary plaque burden (p=0.080), while IgA against P.gingivalis tended to be associated with incident MACE (p=0.060). Conclusion: Plasma IgG and IgA against major periodontal pathogens were not associated with the extent of coronary atherosclerosis (with the exception of a trend in diabetics) nor with coronary plaque vulnerability. IgA against periodontal pathogens were inversely associated with extent of coronary remodeling. Altogether, these results do not add evidence for a substantial role of systemic exposure to periodontal pathogens in coronary artery disease.
AB - Objective: Previous studies have suggested positive associations between periodontal infection and cardiovascular disease. We aimed to investigate the associations of circulating antibodies against periodontal pathogens with 1-year cardiovascular outcome, as well as the extent of coronary atherosclerosis, plaque vulnerability and lesion remodeling on intravascular ultrasound (IVUS) imaging. Methods: Between 2008 and 2011, radiofrequency IVUS imaging of a non-culprit coronary artery was performed in 581 patients who underwent coronary angiography. Immunoglobulin G (IgG) and A (IgA) against Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Tannerella forsythia and Prevotella intermedia were measured in plasma. Results: None of the antibody levels were associated with coronary plaque burden, radiofreqeuncy-IVUS-derived thin-cap fibroatheroma lesion morphology or 1-year incidence of major adverse cardiac events (MACE), which included all-cause mortality, acute coronary syndrome and unplanned coronary revascularization. IgA against A.actinomycetemcomitans, T.forsythia and P.intermedia were inversely associated with extent of positive lesion remodeling (OR for highest versus lowest tertile 0.55, 95%CI 0.35-0.88, p=0.012; 0.53, 95%CI 0.32-0.87, p=0.012; and 0.64, 95%CI 0.40-1.02, p=0.061, respectively). In diabetic patients specifically, IgG against P.gingivalis tended to be associated with coronary plaque burden (p=0.080), while IgA against P.gingivalis tended to be associated with incident MACE (p=0.060). Conclusion: Plasma IgG and IgA against major periodontal pathogens were not associated with the extent of coronary atherosclerosis (with the exception of a trend in diabetics) nor with coronary plaque vulnerability. IgA against periodontal pathogens were inversely associated with extent of coronary remodeling. Altogether, these results do not add evidence for a substantial role of systemic exposure to periodontal pathogens in coronary artery disease.
KW - Atherosclerosis
KW - Coronary artery disease
KW - Periodontitis
KW - Prognosis
KW - Serology
UR - https://www.scopus.com/pages/publications/84907764688
U2 - 10.1016/j.atherosclerosis.2014.08.050
DO - 10.1016/j.atherosclerosis.2014.08.050
M3 - Article
C2 - 25233105
AN - SCOPUS:84907764688
SN - 0021-9150
VL - 237
SP - 84
EP - 91
JO - Atherosclerosis
JF - Atherosclerosis
IS - 1
ER -
