An evaluation of preoperative CA 15-3 measurement in primary breast carcinoma

Dm O'hanlon; M. J. Kerin; P Kent; D Maher; H Grimes; H Frederick Given

doi:10.13025/23422

An evaluation of preoperative CA 15-3 measurement in primary breast carcinoma

Dm O'hanlon
, M. J. Kerin
, P Kent
, D Maher
, H Grimes
, H Frederick Given

Surgery

Galway University Hospital

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

59 Citations (Scopus)

Abstract

In this study of 500 patients with breast carcinoma, we have prospectively assessed the role of preoperative CA 15-3 as a marker of disease burden over a 7 year period. CA 15-3 levels at presentation correlate with stage of disease, tumour size, lymph node status, the presence of metastases and lymphocyte infiltration into the tumour. CA 15-3 alone is not an independent prognostic indicator, although a serum level of > 40 U ml-1 has a positive predictive value of 83% for the presence of advanced disease. We recommend the routine use of this marker in the preoperative assessment of primary breast carcinoma.

Original language	English
Pages (from-to)	1288-1291
Number of pages	4
Journal	British Journal of Cancer
Volume	71
Issue number	6
DOIs	https://doi.org/10.13025/23422 https://doi.org/10.1038/bjc.1995.249
Publication status	Published - Jun 1995

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Breast neoplasia
CA 15-3
Tumour marker

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10.13025/23422Licence: CC BY-NC-ND
10.1038/bjc.1995.249

Cite this

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title = "An evaluation of preoperative CA 15-3 measurement in primary breast carcinoma",

abstract = "In this study of 500 patients with breast carcinoma, we have prospectively assessed the role of preoperative CA 15-3 as a marker of disease burden over a 7 year period. CA 15-3 levels at presentation correlate with stage of disease, tumour size, lymph node status, the presence of metastases and lymphocyte infiltration into the tumour. CA 15-3 alone is not an independent prognostic indicator, although a serum level of > 40 U ml-1 has a positive predictive value of 83\% for the presence of advanced disease. We recommend the routine use of this marker in the preoperative assessment of primary breast carcinoma.",

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AU - O'hanlon, Dm

AU - Kerin, M. J.

AU - Kent, P

AU - Maher, D

AU - Grimes, H

AU - Given, H Frederick

PY - 1995/6

Y1 - 1995/6

N2 - In this study of 500 patients with breast carcinoma, we have prospectively assessed the role of preoperative CA 15-3 as a marker of disease burden over a 7 year period. CA 15-3 levels at presentation correlate with stage of disease, tumour size, lymph node status, the presence of metastases and lymphocyte infiltration into the tumour. CA 15-3 alone is not an independent prognostic indicator, although a serum level of > 40 U ml-1 has a positive predictive value of 83% for the presence of advanced disease. We recommend the routine use of this marker in the preoperative assessment of primary breast carcinoma.

AB - In this study of 500 patients with breast carcinoma, we have prospectively assessed the role of preoperative CA 15-3 as a marker of disease burden over a 7 year period. CA 15-3 levels at presentation correlate with stage of disease, tumour size, lymph node status, the presence of metastases and lymphocyte infiltration into the tumour. CA 15-3 alone is not an independent prognostic indicator, although a serum level of > 40 U ml-1 has a positive predictive value of 83% for the presence of advanced disease. We recommend the routine use of this marker in the preoperative assessment of primary breast carcinoma.

KW - Breast neoplasia

KW - CA 15-3

KW - Tumour marker

UR - http://hdl.handle.net/10379/9731

UR - https://www.scopus.com/pages/publications/0029057399

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SP - 1288

EP - 1291

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 6

ER -

An evaluation of preoperative CA 15-3 measurement in primary breast carcinoma

Abstract

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Keywords

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