TY - GEN
T1 - Along-Tract Statistical Mapping of Microstructural Abnormalities in Bipolar Disorder
T2 - 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference, EMBC 2023
AU - Nabulsi, Leila
AU - Chandio, Bramsh Q.
AU - Dhinagar, Nikhil
AU - Laltoo, Emily
AU - McPhilemy, Genevieve
AU - Martyn, Fiona M.
AU - Hallahan, Brian
AU - McDonald, Colm
AU - Thompson, Paul M.
AU - Cannon, Dara M.
N1 - Publisher Copyright:
© 2023 IEEE.
PY - 2023
Y1 - 2023
N2 - Investigating brain circuitry involved in bipolar disorder (BD) is key to discovering brain biomarkers for genetic and interventional studies of the disorder. Even so, prior research has not provided a fine-scale spatial mapping of brain microstructural differences in BD. In this pilot diffusion MRI dataset, we used BUndle ANalytics (BUAN) - a recently developed analytic approach for tractography - to extract, map, and visualize the profile of microstructural abnormalities on a 3D model of fiber tracts in people with BD (N=38) and healthy controls (N=49), and investigate along-tract white matter (WM) microstructural differences between these groups. Using the BUAN pipeline, BD was associated with lower mean fractional anisotropy (FA) in fronto-limbic and interhemispheric pathways and higher mean FA in posterior bundles relative to controls.Clinical Relevance - BUAN combines tractography and anatomical information to capture distinct along-tract effects on WM microstructure that may aid in classifying diseases based on anatomical differences.
AB - Investigating brain circuitry involved in bipolar disorder (BD) is key to discovering brain biomarkers for genetic and interventional studies of the disorder. Even so, prior research has not provided a fine-scale spatial mapping of brain microstructural differences in BD. In this pilot diffusion MRI dataset, we used BUndle ANalytics (BUAN) - a recently developed analytic approach for tractography - to extract, map, and visualize the profile of microstructural abnormalities on a 3D model of fiber tracts in people with BD (N=38) and healthy controls (N=49), and investigate along-tract white matter (WM) microstructural differences between these groups. Using the BUAN pipeline, BD was associated with lower mean fractional anisotropy (FA) in fronto-limbic and interhemispheric pathways and higher mean FA in posterior bundles relative to controls.Clinical Relevance - BUAN combines tractography and anatomical information to capture distinct along-tract effects on WM microstructure that may aid in classifying diseases based on anatomical differences.
UR - https://www.scopus.com/pages/publications/85179649752
U2 - 10.1109/EMBC40787.2023.10339964
DO - 10.1109/EMBC40787.2023.10339964
M3 - Conference Publication
C2 - 38083303
AN - SCOPUS:85179649752
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
BT - 2023 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference, EMBC 2023 - Proceedings
PB - Institute of Electrical and Electronics Engineers Inc.
Y2 - 24 July 2023 through 27 July 2023
ER -