Adverse reactions after the use of sulphur hexafluoride (SonoVue) echo contrast agent

Marcel L. Geleijnse; Attila Nemes; Wim B. Vletter; Michelle Michels; Osama Ii Soliman; Kadir Caliskan; Tjebbe W. Galema; Folkert J. Ten Cate

doi:10.2459/JCM.0b013e328319bfba

Adverse reactions after the use of sulphur hexafluoride (SonoVue) echo contrast agent

Marcel L. Geleijnse
, Attila Nemes
, Wim B. Vletter
, Michelle Michels
, Osama Ii Soliman
, Kadir Caliskan
, Tjebbe W. Galema
, Folkert J. Ten Cate

Erasmus MC

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

48 Citations (Scopus)

Abstract

The aim of the present study was to analyse the adverse effects of SonoVue echo contrast in a consecutive series of 352 cardiac patients during a 4-year period. During 352 consecutive cardiac SonoVue studies, seven patients (2.0%) experienced adverse effects. Four patients (1.1%) had mild allergic reactions causing skin erythema and mild sinus tachycardia, and three patients (0.9%) experienced a severe allergic reaction resulting in (nonfatal) shock. The reported incidence of adverse effects of SonoVue echo contrast in this consecutive series of cardiac patients seems markedly higher than those reported in a company postmarketing analysis.

Original language	English
Pages (from-to)	75-77
Number of pages	3
Journal	Journal of Cardiovascular Medicine
Volume	10
Issue number	1
DOIs	https://doi.org/10.2459/JCM.0b013e328319bfba
Publication status	Published - Jan 2009
Externally published	Yes

Keywords

Adverse reactions
Contrast agent
Sulphur hexafluoride

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10.2459/JCM.0b013e328319bfba

Cite this

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title = "Adverse reactions after the use of sulphur hexafluoride (SonoVue) echo contrast agent",

abstract = "The aim of the present study was to analyse the adverse effects of SonoVue echo contrast in a consecutive series of 352 cardiac patients during a 4-year period. During 352 consecutive cardiac SonoVue studies, seven patients (2.0\%) experienced adverse effects. Four patients (1.1\%) had mild allergic reactions causing skin erythema and mild sinus tachycardia, and three patients (0.9\%) experienced a severe allergic reaction resulting in (nonfatal) shock. The reported incidence of adverse effects of SonoVue echo contrast in this consecutive series of cardiac patients seems markedly higher than those reported in a company postmarketing analysis.",

keywords = "Adverse reactions, Contrast agent, Sulphur hexafluoride",

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doi = "10.2459/JCM.0b013e328319bfba",

language = "English",

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T1 - Adverse reactions after the use of sulphur hexafluoride (SonoVue) echo contrast agent

AU - Geleijnse, Marcel L.

AU - Nemes, Attila

AU - Vletter, Wim B.

AU - Michels, Michelle

AU - Soliman, Osama Ii

AU - Caliskan, Kadir

AU - Galema, Tjebbe W.

AU - Ten Cate, Folkert J.

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Y1 - 2009/1

N2 - The aim of the present study was to analyse the adverse effects of SonoVue echo contrast in a consecutive series of 352 cardiac patients during a 4-year period. During 352 consecutive cardiac SonoVue studies, seven patients (2.0%) experienced adverse effects. Four patients (1.1%) had mild allergic reactions causing skin erythema and mild sinus tachycardia, and three patients (0.9%) experienced a severe allergic reaction resulting in (nonfatal) shock. The reported incidence of adverse effects of SonoVue echo contrast in this consecutive series of cardiac patients seems markedly higher than those reported in a company postmarketing analysis.

AB - The aim of the present study was to analyse the adverse effects of SonoVue echo contrast in a consecutive series of 352 cardiac patients during a 4-year period. During 352 consecutive cardiac SonoVue studies, seven patients (2.0%) experienced adverse effects. Four patients (1.1%) had mild allergic reactions causing skin erythema and mild sinus tachycardia, and three patients (0.9%) experienced a severe allergic reaction resulting in (nonfatal) shock. The reported incidence of adverse effects of SonoVue echo contrast in this consecutive series of cardiac patients seems markedly higher than those reported in a company postmarketing analysis.

KW - Adverse reactions

KW - Contrast agent

KW - Sulphur hexafluoride

UR - https://www.scopus.com/pages/publications/67650924220

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DO - 10.2459/JCM.0b013e328319bfba

M3 - Article

SN - 1558-2027

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SP - 75

EP - 77

JO - Journal of Cardiovascular Medicine

JF - Journal of Cardiovascular Medicine

IS - 1

ER -

Adverse reactions after the use of sulphur hexafluoride (SonoVue) echo contrast agent

Abstract

Keywords

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