Advances in polymeric islet cell encapsulation technologies to limit the foreign body response and provide immunoisolation

Alan J. Ryan; Hugh S. O'Neill; Garry P. Duffy; Fergal J. O'Brien

doi:10.1016/j.coph.2017.07.013

Advances in polymeric islet cell encapsulation technologies to limit the foreign body response and provide immunoisolation

Alan J. Ryan, Hugh S. O'Neill, Garry P. Duffy, Fergal J. O'Brien

Research output: Contribution to a Journal (Peer & Non Peer) › Review article › peer-review

29 Citations (Scopus)

Abstract

Islet transplantation for the treatment of type 1 diabetes (T1D) is hampered by the shortage of donor tissue and the need for life-long immunosuppression. The engineering of materials to limit host immune rejection opens the possibilities of utilising allogeneic and even xenogeneic cells without the need for systemic immunosuppression. Here we discuss the most recent developments in immunoisolation of transplanted cells using advanced polymeric biomaterials, utilising macroscale to nanoscale approaches, to limit aberrant immune responses.

Original language	English
Pages (from-to)	66-71
Number of pages	6
Journal	Current Opinion in Pharmacology
Volume	36
DOIs	https://doi.org/10.1016/j.coph.2017.07.013
Publication status	Published - Oct 2017

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10.1016/j.coph.2017.07.013

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title = "Advances in polymeric islet cell encapsulation technologies to limit the foreign body response and provide immunoisolation",

abstract = "Islet transplantation for the treatment of type 1 diabetes (T1D) is hampered by the shortage of donor tissue and the need for life-long immunosuppression. The engineering of materials to limit host immune rejection opens the possibilities of utilising allogeneic and even xenogeneic cells without the need for systemic immunosuppression. Here we discuss the most recent developments in immunoisolation of transplanted cells using advanced polymeric biomaterials, utilising macroscale to nanoscale approaches, to limit aberrant immune responses.",

author = "Ryan, \{Alan J.\} and O'Neill, \{Hugh S.\} and Duffy, \{Garry P.\} and O'Brien, \{Fergal J.\}",

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doi = "10.1016/j.coph.2017.07.013",

language = "English",

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AU - Ryan, Alan J.

AU - O'Neill, Hugh S.

AU - Duffy, Garry P.

AU - O'Brien, Fergal J.

PY - 2017/10

Y1 - 2017/10

N2 - Islet transplantation for the treatment of type 1 diabetes (T1D) is hampered by the shortage of donor tissue and the need for life-long immunosuppression. The engineering of materials to limit host immune rejection opens the possibilities of utilising allogeneic and even xenogeneic cells without the need for systemic immunosuppression. Here we discuss the most recent developments in immunoisolation of transplanted cells using advanced polymeric biomaterials, utilising macroscale to nanoscale approaches, to limit aberrant immune responses.

AB - Islet transplantation for the treatment of type 1 diabetes (T1D) is hampered by the shortage of donor tissue and the need for life-long immunosuppression. The engineering of materials to limit host immune rejection opens the possibilities of utilising allogeneic and even xenogeneic cells without the need for systemic immunosuppression. Here we discuss the most recent developments in immunoisolation of transplanted cells using advanced polymeric biomaterials, utilising macroscale to nanoscale approaches, to limit aberrant immune responses.

UR - https://www.scopus.com/pages/publications/85029287382

U2 - 10.1016/j.coph.2017.07.013

DO - 10.1016/j.coph.2017.07.013

M3 - Review article

SN - 1471-4892

VL - 36

SP - 66

EP - 71

JO - Current Opinion in Pharmacology

JF - Current Opinion in Pharmacology

ER -

Advances in polymeric islet cell encapsulation technologies to limit the foreign body response and provide immunoisolation

Abstract

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