Additional cytotoxic pyridoacridine alkaloids from the ascidian cystodytes violatinctus and biogenetic considerations

Nataly Bontemps; Florence Gattacceca; Christophe Long; Olivier P. Thomas; Bernard Banaigs

doi:10.1021/np400284z

Additional cytotoxic pyridoacridine alkaloids from the ascidian cystodytes violatinctus and biogenetic considerations

Nataly Bontemps, Florence Gattacceca, Christophe Long, Olivier P. Thomas, Bernard Banaigs

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

25 Citations (Scopus)

Abstract

The extraction and purification of the bioactive extract of Cystodytes violatinctus (Solomon Islands) led to the isolation and identification of six pyridoacridine alkaloids. The structures of four new members of this family, shermilamine F (1), dehydrokuanoniamine F (2), and arnoamines C (3) and D (4), were elucidated on the basis of NMR and MS data and by comparison with data of known compounds isolated from this genus. A general hypothetical biogenetic pathway is then proposed for pyridoacridine alkaloids that contain a fused pyrrole ring. Comparison of the biological properties of the isolated alkaloids is also discussed.

Original language	English
Pages (from-to)	1801-1805
Number of pages	5
Journal	Journal of Natural Products
Volume	76
Issue number	9
DOIs	https://doi.org/10.1021/np400284z
Publication status	Published - 27 Sep 2013
Externally published	Yes

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title = "Additional cytotoxic pyridoacridine alkaloids from the ascidian cystodytes violatinctus and biogenetic considerations",

abstract = "The extraction and purification of the bioactive extract of Cystodytes violatinctus (Solomon Islands) led to the isolation and identification of six pyridoacridine alkaloids. The structures of four new members of this family, shermilamine F (1), dehydrokuanoniamine F (2), and arnoamines C (3) and D (4), were elucidated on the basis of NMR and MS data and by comparison with data of known compounds isolated from this genus. A general hypothetical biogenetic pathway is then proposed for pyridoacridine alkaloids that contain a fused pyrrole ring. Comparison of the biological properties of the isolated alkaloids is also discussed.",

author = "Nataly Bontemps and Florence Gattacceca and Christophe Long and Thomas, \{Olivier P.\} and Bernard Banaigs",

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T1 - Additional cytotoxic pyridoacridine alkaloids from the ascidian cystodytes violatinctus and biogenetic considerations

AU - Bontemps, Nataly

AU - Gattacceca, Florence

AU - Long, Christophe

AU - Thomas, Olivier P.

AU - Banaigs, Bernard

PY - 2013/9/27

Y1 - 2013/9/27

N2 - The extraction and purification of the bioactive extract of Cystodytes violatinctus (Solomon Islands) led to the isolation and identification of six pyridoacridine alkaloids. The structures of four new members of this family, shermilamine F (1), dehydrokuanoniamine F (2), and arnoamines C (3) and D (4), were elucidated on the basis of NMR and MS data and by comparison with data of known compounds isolated from this genus. A general hypothetical biogenetic pathway is then proposed for pyridoacridine alkaloids that contain a fused pyrrole ring. Comparison of the biological properties of the isolated alkaloids is also discussed.

AB - The extraction and purification of the bioactive extract of Cystodytes violatinctus (Solomon Islands) led to the isolation and identification of six pyridoacridine alkaloids. The structures of four new members of this family, shermilamine F (1), dehydrokuanoniamine F (2), and arnoamines C (3) and D (4), were elucidated on the basis of NMR and MS data and by comparison with data of known compounds isolated from this genus. A general hypothetical biogenetic pathway is then proposed for pyridoacridine alkaloids that contain a fused pyrrole ring. Comparison of the biological properties of the isolated alkaloids is also discussed.

UR - https://www.scopus.com/pages/publications/84885060268

U2 - 10.1021/np400284z

DO - 10.1021/np400284z

M3 - Article

SN - 0163-3864

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SP - 1801

EP - 1805

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 9

ER -

Additional cytotoxic pyridoacridine alkaloids from the ascidian cystodytes violatinctus and biogenetic considerations

Abstract

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