TY - JOUR
T1 - Adaptive living skills, sleep problems, and mental health disorders in adults with 22q11.21 deletion syndrome
AU - Leader, Geraldine
AU - Curtin, Andrea
AU - Shprintzen, Robert J.
AU - Whelan, Sally
AU - Coyne, Rory
AU - Mannion, Arlene
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023/5
Y1 - 2023/5
N2 - Background: 22q11.21 deletion syndrome (22q11DS) is a neurodevelopmental syndrome caused by a microdeletion of genes at the 22q11.21 locus. It has a prevalence of 1:2000. This study investigated the prevalence of adaptive living skills, sleep problems, and mental health disorders in adults with 22q11DS and examined the relationship between these factors. Methods: Parents with an adult son or daughter with 22q11DS completed the following: A bespoke Demographic Information Questionnaire, Sleep Questionnaire (SQ-SP), Psychopathology in Autism Checklist (PAC), and Activities of Daily Living (ADL) scale. Descriptive statistics, correlations, and one-way between groups analysis of variance (ANOVA) were conducted. Results: Mental health difficulties, sleep problems, and low levels of adaptive living skills are prevalent in adults with 22q11DS. Strong positive correlations were identified between sleep problems, depression, and anxiety subscale scores and moderate negative correlations between depression, psychosis, and activities of daily living skills. Conclusion: Adults with 22q11DS need screening and treatment for mental health and sleep problems.
AB - Background: 22q11.21 deletion syndrome (22q11DS) is a neurodevelopmental syndrome caused by a microdeletion of genes at the 22q11.21 locus. It has a prevalence of 1:2000. This study investigated the prevalence of adaptive living skills, sleep problems, and mental health disorders in adults with 22q11DS and examined the relationship between these factors. Methods: Parents with an adult son or daughter with 22q11DS completed the following: A bespoke Demographic Information Questionnaire, Sleep Questionnaire (SQ-SP), Psychopathology in Autism Checklist (PAC), and Activities of Daily Living (ADL) scale. Descriptive statistics, correlations, and one-way between groups analysis of variance (ANOVA) were conducted. Results: Mental health difficulties, sleep problems, and low levels of adaptive living skills are prevalent in adults with 22q11DS. Strong positive correlations were identified between sleep problems, depression, and anxiety subscale scores and moderate negative correlations between depression, psychosis, and activities of daily living skills. Conclusion: Adults with 22q11DS need screening and treatment for mental health and sleep problems.
KW - Conotruncal anomaly face syndrome
KW - DiGeorge syndrome
KW - Sedlačková syndrome
KW - Velo-cardio-facial syndrome
UR - https://www.scopus.com/pages/publications/85150492678
U2 - 10.1016/j.ridd.2023.104491
DO - 10.1016/j.ridd.2023.104491
M3 - Article
C2 - 36965410
AN - SCOPUS:85150492678
SN - 0891-4222
VL - 136
JO - Research in Developmental Disabilities
JF - Research in Developmental Disabilities
M1 - 104491
ER -