Acute ethanol decreases NPY mRNA but not POMC mRNA in the arcuate nucleus

Hiroshi Kinoshita; David S. Jessop; David P. Finn; Toni L. Coventry; David J. Roberts; Kiyoshi Ameno; Iwao Ijiri; Michael S. Harbuz

doi:10.1097/00001756-200011090-00023

Acute ethanol decreases NPY mRNA but not POMC mRNA in the arcuate nucleus

Hiroshi Kinoshita
, David S. Jessop
, David P. Finn
, Toni L. Coventry
, David J. Roberts
, Kiyoshi Ameno
, Iwao Ijiri
, Michael S. Harbuz

University of Bristol
Kagawa Medical University

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

31 Citations (Scopus)

Abstract

The acute effects of ethanol and acetaldehyde on neuropeptide mRNA expression in the arcuate nucleus (ARC) was assessed. Acetaldehyde was increased in blood following ethanol with cyanamide (a potent inhibitor of aldehyde dehydrogenase) administration. Acetaldehyde is a toxin which can cause a variety of adverse effects following ethanol ingestion in some Oriental people with a genetic lower activity of aldehyde dehydrogenase. Neuropeptide Y (NPY) mRNA levels in ARC were significantly decreased in response to ethanol in the presence or absence of cyanamide compared to control. In contrast, proopiomelanocortin mRNA in ARC was not changed. These novel findings suggest that ethanol suppresses NPY gene expression in ARC and may play a role in ethanol-induced changes in neuronal function. (C) 2000 Lippincott Williams and Wilkins.

Original language	English
Pages (from-to)	3517-3519
Number of pages	3
Journal	NeuroReport
Volume	11
Issue number	16
DOIs	https://doi.org/10.1097/00001756-200011090-00023
Publication status	Published - 9 Nov 2000
Externally published	Yes

Keywords

Acetaldehyde
Arcuate nucleus
Cyanamide
Ethanol
In situ hybridization
Neuropeptide Y mRNA
Proopiomelanocortin mRNA

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10.1097/00001756-200011090-00023

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title = "Acute ethanol decreases NPY mRNA but not POMC mRNA in the arcuate nucleus",

abstract = "The acute effects of ethanol and acetaldehyde on neuropeptide mRNA expression in the arcuate nucleus (ARC) was assessed. Acetaldehyde was increased in blood following ethanol with cyanamide (a potent inhibitor of aldehyde dehydrogenase) administration. Acetaldehyde is a toxin which can cause a variety of adverse effects following ethanol ingestion in some Oriental people with a genetic lower activity of aldehyde dehydrogenase. Neuropeptide Y (NPY) mRNA levels in ARC were significantly decreased in response to ethanol in the presence or absence of cyanamide compared to control. In contrast, proopiomelanocortin mRNA in ARC was not changed. These novel findings suggest that ethanol suppresses NPY gene expression in ARC and may play a role in ethanol-induced changes in neuronal function. (C) 2000 Lippincott Williams and Wilkins.",

keywords = "Acetaldehyde, Arcuate nucleus, Cyanamide, Ethanol, In situ hybridization, Neuropeptide Y mRNA, Proopiomelanocortin mRNA",

author = "Hiroshi Kinoshita and Jessop, \{David S.\} and Finn, \{David P.\} and Coventry, \{Toni L.\} and Roberts, \{David J.\} and Kiyoshi Ameno and Iwao Ijiri and Harbuz, \{Michael S.\}",

year = "2000",

month = nov,

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doi = "10.1097/00001756-200011090-00023",

language = "English",

volume = "11",

pages = "3517--3519",

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TY - JOUR

T1 - Acute ethanol decreases NPY mRNA but not POMC mRNA in the arcuate nucleus

AU - Kinoshita, Hiroshi

AU - Jessop, David S.

AU - Finn, David P.

AU - Coventry, Toni L.

AU - Roberts, David J.

AU - Ameno, Kiyoshi

AU - Ijiri, Iwao

AU - Harbuz, Michael S.

PY - 2000/11/9

Y1 - 2000/11/9

N2 - The acute effects of ethanol and acetaldehyde on neuropeptide mRNA expression in the arcuate nucleus (ARC) was assessed. Acetaldehyde was increased in blood following ethanol with cyanamide (a potent inhibitor of aldehyde dehydrogenase) administration. Acetaldehyde is a toxin which can cause a variety of adverse effects following ethanol ingestion in some Oriental people with a genetic lower activity of aldehyde dehydrogenase. Neuropeptide Y (NPY) mRNA levels in ARC were significantly decreased in response to ethanol in the presence or absence of cyanamide compared to control. In contrast, proopiomelanocortin mRNA in ARC was not changed. These novel findings suggest that ethanol suppresses NPY gene expression in ARC and may play a role in ethanol-induced changes in neuronal function. (C) 2000 Lippincott Williams and Wilkins.

AB - The acute effects of ethanol and acetaldehyde on neuropeptide mRNA expression in the arcuate nucleus (ARC) was assessed. Acetaldehyde was increased in blood following ethanol with cyanamide (a potent inhibitor of aldehyde dehydrogenase) administration. Acetaldehyde is a toxin which can cause a variety of adverse effects following ethanol ingestion in some Oriental people with a genetic lower activity of aldehyde dehydrogenase. Neuropeptide Y (NPY) mRNA levels in ARC were significantly decreased in response to ethanol in the presence or absence of cyanamide compared to control. In contrast, proopiomelanocortin mRNA in ARC was not changed. These novel findings suggest that ethanol suppresses NPY gene expression in ARC and may play a role in ethanol-induced changes in neuronal function. (C) 2000 Lippincott Williams and Wilkins.

KW - Acetaldehyde

KW - Arcuate nucleus

KW - Cyanamide

KW - Ethanol

KW - In situ hybridization

KW - Neuropeptide Y mRNA

KW - Proopiomelanocortin mRNA

UR - https://www.scopus.com/pages/publications/0034626977

U2 - 10.1097/00001756-200011090-00023

DO - 10.1097/00001756-200011090-00023

M3 - Article

SN - 0959-4965

VL - 11

SP - 3517

EP - 3519

JO - NeuroReport

JF - NeuroReport

IS - 16

ER -

Acute ethanol decreases NPY mRNA but not POMC mRNA in the arcuate nucleus

Abstract

Keywords

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