Acetal-linked branched poly(dimethyl-aminoethyl methacrylate) as an acid cleavable gene vector with reduced cytotoxicity

H. L. Cao; Y. X. Dong; A. Aied; T. Y. Zhao; X. Chen; W. X. Wang; A. Pandit

doi:10.1039/c4cc06728b

Acetal-linked branched poly(dimethyl-aminoethyl methacrylate) as an acid cleavable gene vector with reduced cytotoxicity

H. L. Cao
, Y. X. Dong
, A. Aied
, T. Y. Zhao
, X. Chen
, W. X. Wang
, A. Pandit

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

17 Citations (Scopus)

Abstract

An acid labile branched PDMAEMA/acetal copolymer with amino group was synthesized by the DE-ATRP and followed by Michael addition. The degradation of the polymer was strongly pH-dependent. High nucleic acid transfection efficiency with low cytotoxicity was observed compared to its non-degradable copolymer counterpart. 2014

Original language	English
Pages (from-to)	15565-15568
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	98
DOIs	https://doi.org/10.1039/c4cc06728b
Publication status	Published - 13 Nov 2014
Externally published	Yes

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title = "Acetal-linked branched poly(dimethyl-aminoethyl methacrylate) as an acid cleavable gene vector with reduced cytotoxicity",

abstract = "An acid labile branched PDMAEMA/acetal copolymer with amino group was synthesized by the DE-ATRP and followed by Michael addition. The degradation of the polymer was strongly pH-dependent. High nucleic acid transfection efficiency with low cytotoxicity was observed compared to its non-degradable copolymer counterpart. 2014",

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AU - Cao, H. L.

AU - Dong, Y. X.

AU - Aied, A.

AU - Zhao, T. Y.

AU - Chen, X.

AU - Wang, W. X.

AU - Pandit, A.

PY - 2014/11/13

Y1 - 2014/11/13

N2 - An acid labile branched PDMAEMA/acetal copolymer with amino group was synthesized by the DE-ATRP and followed by Michael addition. The degradation of the polymer was strongly pH-dependent. High nucleic acid transfection efficiency with low cytotoxicity was observed compared to its non-degradable copolymer counterpart. 2014

AB - An acid labile branched PDMAEMA/acetal copolymer with amino group was synthesized by the DE-ATRP and followed by Michael addition. The degradation of the polymer was strongly pH-dependent. High nucleic acid transfection efficiency with low cytotoxicity was observed compared to its non-degradable copolymer counterpart. 2014

UR - https://www.scopus.com/pages/publications/84912098440

U2 - 10.1039/c4cc06728b

DO - 10.1039/c4cc06728b

M3 - Article

SN - 1359-7345

VL - 50

SP - 15565

EP - 15568

JO - Chemical Communications

JF - Chemical Communications

IS - 98

ER -

Acetal-linked branched poly(dimethyl-aminoethyl methacrylate) as an acid cleavable gene vector with reduced cytotoxicity

Abstract

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