A termination site for Xenopus RNA polymerase I also acts as an element of an adjacent promoter

Brian McStay; Ronald H. Reeder

doi:10.1016/0092-8674(86)90806-8

A termination site for Xenopus RNA polymerase I also acts as an element of an adjacent promoter

Brian McStay
, Ronald H. Reeder

Fred Hutchinson Cancer Center

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

80 Citations (Scopus)

Abstract

On the Xenopus laevis ribosomal genes, RNA polymerase traverses the entire repeating unit of gene plus spacer and terminates just upstream of the next gene promoter. A conserved 7 bp element located at about -200 is an essential part of this terminator. In this paper we show that, in addition to its termination function, this same sequence motif acts as an upstream element of the adjacent promoter and appears to contribute to the long-term stability of the transcription complex.

Original language	English
Pages (from-to)	913-920
Number of pages	8
Journal	Cell
Volume	47
Issue number	6
DOIs	https://doi.org/10.1016/0092-8674(86)90806-8
Publication status	Published - 26 Dec 1986
Externally published	Yes

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10.1016/0092-8674(86)90806-8

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title = "A termination site for Xenopus RNA polymerase I also acts as an element of an adjacent promoter",

abstract = "On the Xenopus laevis ribosomal genes, RNA polymerase traverses the entire repeating unit of gene plus spacer and terminates just upstream of the next gene promoter. A conserved 7 bp element located at about -200 is an essential part of this terminator. In this paper we show that, in addition to its termination function, this same sequence motif acts as an upstream element of the adjacent promoter and appears to contribute to the long-term stability of the transcription complex.",

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AU - McStay, Brian

AU - Reeder, Ronald H.

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N2 - On the Xenopus laevis ribosomal genes, RNA polymerase traverses the entire repeating unit of gene plus spacer and terminates just upstream of the next gene promoter. A conserved 7 bp element located at about -200 is an essential part of this terminator. In this paper we show that, in addition to its termination function, this same sequence motif acts as an upstream element of the adjacent promoter and appears to contribute to the long-term stability of the transcription complex.

AB - On the Xenopus laevis ribosomal genes, RNA polymerase traverses the entire repeating unit of gene plus spacer and terminates just upstream of the next gene promoter. A conserved 7 bp element located at about -200 is an essential part of this terminator. In this paper we show that, in addition to its termination function, this same sequence motif acts as an upstream element of the adjacent promoter and appears to contribute to the long-term stability of the transcription complex.

UR - https://www.scopus.com/pages/publications/0022870077

U2 - 10.1016/0092-8674(86)90806-8

DO - 10.1016/0092-8674(86)90806-8

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VL - 47

SP - 913

EP - 920

JO - Cell

JF - Cell

IS - 6

ER -

A termination site for Xenopus RNA polymerase I also acts as an element of an adjacent promoter

Abstract

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