A pathogenesis-based transcript signature in donor-specific antibody-positive kidney transplant patients with normal biopsies

Pilib Ó Broin

A pathogenesis-based transcript signature in donor-specific antibody-positive kidney transplant patients with normal biopsies

Pilib Ó Broin

Mathematics

Albert Einstein College of Medicine
The University of Texas Health Science Center at Houston
Yeshiva University

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

9 Citations (Scopus)

Abstract

Affymetrix Human Gene 1.0-ST arrays were used to assess the gene expression profiles of kidney transplant patients who presented with donor-specific antibodies (DSAs) but showed normal biopsy histopathology and did not develop antibody-mediated rejection (AMR). Biopsy and whole-blood profiles for these DSA-positive, AMR-negative (DSA. +/AMR-) patients were compared to both DSA-positive, AMR-positive (DSA. +/AMR. +) patients as well as DSA-negative (DSA. -) controls. While individual gene expression changes across sample groups were relatively subtle, gene-set enrichment analysis using previously identified pathogenesis-based transcripts (PBTs) identified a clear molecular signature involving increased rejection-associated transcripts in AMR. - patients. Results from this study have been published in Kidney International (Hayde et al., 2014 [1]) and the associated data have been deposited in the GEO archive and are accessible via the following link: http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE50084.

Original language	English (Ireland)
Pages (from-to)	357-360
Number of pages	4
Journal	Genomics Data
Volume	2
Publication status	Published - 1 Jan 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antibody-mediated rejection
Donor-specific antibodies
Gene expression
Kidney
Transplant

Authors (Note for portal: view the doc link for the full list of authors)

Authors
Ó Broin, P and Hayde, N and Bao, Y and Ye, B and Calder, RB and de Boccardo, G and Lubetzky, M and Ajaimy, M and Pullman, J and Colovai, A and others
Broin, P \'O and Hayde, N and Bao, Y and Ye, B and Calder, RB and de Boccardo, G and Lubetzky, M and Ajaimy, M and Pullman, J and Colovai, A and others

Cite this

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title = "A pathogenesis-based transcript signature in donor-specific antibody-positive kidney transplant patients with normal biopsies",

abstract = "Affymetrix Human Gene 1.0-ST arrays were used to assess the gene expression profiles of kidney transplant patients who presented with donor-specific antibodies (DSAs) but showed normal biopsy histopathology and did not develop antibody-mediated rejection (AMR). Biopsy and whole-blood profiles for these DSA-positive, AMR-negative (DSA. +/AMR-) patients were compared to both DSA-positive, AMR-positive (DSA. +/AMR. +) patients as well as DSA-negative (DSA. -) controls. While individual gene expression changes across sample groups were relatively subtle, gene-set enrichment analysis using previously identified pathogenesis-based transcripts (PBTs) identified a clear molecular signature involving increased rejection-associated transcripts in AMR. - patients. Results from this study have been published in Kidney International (Hayde et al., 2014 [1]) and the associated data have been deposited in the GEO archive and are accessible via the following link: http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE50084.",

keywords = "Antibody-mediated rejection, Donor-specific antibodies, Gene expression, Kidney, Transplant",

author = "\{{\'O} Broin\}, Pilib",

note = "Publisher Copyright: {\textcopyright} 2014 The Authors.",

year = "2014",

month = jan,

day = "1",

language = "English (Ireland)",

volume = "2",

pages = "357--360",

journal = "Genomics Data",

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TY - JOUR

T1 - A pathogenesis-based transcript signature in donor-specific antibody-positive kidney transplant patients with normal biopsies

AU - Ó Broin, Pilib

PY - 2014/1/1

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N2 - Affymetrix Human Gene 1.0-ST arrays were used to assess the gene expression profiles of kidney transplant patients who presented with donor-specific antibodies (DSAs) but showed normal biopsy histopathology and did not develop antibody-mediated rejection (AMR). Biopsy and whole-blood profiles for these DSA-positive, AMR-negative (DSA. +/AMR-) patients were compared to both DSA-positive, AMR-positive (DSA. +/AMR. +) patients as well as DSA-negative (DSA. -) controls. While individual gene expression changes across sample groups were relatively subtle, gene-set enrichment analysis using previously identified pathogenesis-based transcripts (PBTs) identified a clear molecular signature involving increased rejection-associated transcripts in AMR. - patients. Results from this study have been published in Kidney International (Hayde et al., 2014 [1]) and the associated data have been deposited in the GEO archive and are accessible via the following link: http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE50084.

AB - Affymetrix Human Gene 1.0-ST arrays were used to assess the gene expression profiles of kidney transplant patients who presented with donor-specific antibodies (DSAs) but showed normal biopsy histopathology and did not develop antibody-mediated rejection (AMR). Biopsy and whole-blood profiles for these DSA-positive, AMR-negative (DSA. +/AMR-) patients were compared to both DSA-positive, AMR-positive (DSA. +/AMR. +) patients as well as DSA-negative (DSA. -) controls. While individual gene expression changes across sample groups were relatively subtle, gene-set enrichment analysis using previously identified pathogenesis-based transcripts (PBTs) identified a clear molecular signature involving increased rejection-associated transcripts in AMR. - patients. Results from this study have been published in Kidney International (Hayde et al., 2014 [1]) and the associated data have been deposited in the GEO archive and are accessible via the following link: http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE50084.

KW - Antibody-mediated rejection

KW - Donor-specific antibodies

KW - Gene expression

KW - Kidney

KW - Transplant

UR - https://www.scopus.com/pages/publications/84920549625

M3 - Article

VL - 2

SP - 357

EP - 360

JO - Genomics Data

JF - Genomics Data

ER -

A pathogenesis-based transcript signature in donor-specific antibody-positive kidney transplant patients with normal biopsies

Abstract

UN SDGs

Keywords

Authors (Note for portal: view the doc link for the full list of authors)

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