Abstract
Affymetrix Human Gene 1.0-ST arrays were used to assess the gene expression profiles of kidney transplant patients who presented with donor-specific antibodies (DSAs) but showed normal biopsy histopathology and did not develop antibody-mediated rejection (AMR). Biopsy and whole-blood profiles for these DSA-positive, AMR-negative (DSA. +/AMR-) patients were compared to both DSA-positive, AMR-positive (DSA. +/AMR. +) patients as well as DSA-negative (DSA. -) controls. While individual gene expression changes across sample groups were relatively subtle, gene-set enrichment analysis using previously identified pathogenesis-based transcripts (PBTs) identified a clear molecular signature involving increased rejection-associated transcripts in AMR. - patients. Results from this study have been published in Kidney International (Hayde et al., 2014 [1]) and the associated data have been deposited in the GEO archive and are accessible via the following link: http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE50084.
| Original language | English (Ireland) |
|---|---|
| Pages (from-to) | 357-360 |
| Number of pages | 4 |
| Journal | Genomics Data |
| Volume | 2 |
| Publication status | Published - 1 Jan 2014 |
Keywords
- Antibody-mediated rejection
- Donor-specific antibodies
- Gene expression
- Kidney
- Transplant
Authors (Note for portal: view the doc link for the full list of authors)
- Authors
- Ó Broin, P and Hayde, N and Bao, Y and Ye, B and Calder, RB and de Boccardo, G and Lubetzky, M and Ajaimy, M and Pullman, J and Colovai, A and others
- Broin, P \'O and Hayde, N and Bao, Y and Ye, B and Calder, RB and de Boccardo, G and Lubetzky, M and Ajaimy, M and Pullman, J and Colovai, A and others
