A one-pot, three-component, microwave-promoted synthesis of 2-amino-substituted 7-amino-1,2,4-triazolo[1,5-a][1,3,5]triazines

Svetlana A. Kalinina; Dmitrii V. Kalinin; Anton V. Dolzhenko

doi:10.1016/j.tetlet.2013.07.158

A one-pot, three-component, microwave-promoted synthesis of 2-amino-substituted 7-amino-1,2,4-triazolo[1,5-a][1,3,5]triazines

Svetlana A. Kalinina
, Dmitrii V. Kalinin
, Anton V. Dolzhenko

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

30 Citations (Scopus)

Abstract

A new, efficient, catalyst-free, one-pot, three-component method for the synthesis of 2-amino-substituted 7-amino-1,2,4-triazolo[1,5-a][1,3,5]triazines using 3,5-diamino-1,2,4-triazoles, cyanamide, and triethyl orthoformate is developed. The reaction proceeds smoothly under microwave-assisted heating. Advantages of the method include using easily available reagents, short reaction times, and operational simplicity.

Original language	English
Pages (from-to)	5537-5540
Number of pages	4
Journal	Tetrahedron Letters
Volume	54
Issue number	40
DOIs	https://doi.org/10.1016/j.tetlet.2013.07.158
Publication status	Published - 2 Oct 2013
Externally published	Yes

Keywords

Microwave-assisted synthesis
Multicomponent reaction
Purine isosters
Triazines
Triazoles

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10.1016/j.tetlet.2013.07.158

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title = "A one-pot, three-component, microwave-promoted synthesis of 2-amino-substituted 7-amino-1,2,4-triazolo[1,5-a][1,3,5]triazines",

abstract = "A new, efficient, catalyst-free, one-pot, three-component method for the synthesis of 2-amino-substituted 7-amino-1,2,4-triazolo[1,5-a][1,3,5]triazines using 3,5-diamino-1,2,4-triazoles, cyanamide, and triethyl orthoformate is developed. The reaction proceeds smoothly under microwave-assisted heating. Advantages of the method include using easily available reagents, short reaction times, and operational simplicity.",

keywords = "Microwave-assisted synthesis, Multicomponent reaction, Purine isosters, Triazines, Triazoles",

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year = "2013",

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T1 - A one-pot, three-component, microwave-promoted synthesis of 2-amino-substituted 7-amino-1,2,4-triazolo[1,5-a][1,3,5]triazines

AU - Kalinina, Svetlana A.

AU - Kalinin, Dmitrii V.

AU - Dolzhenko, Anton V.

PY - 2013/10/2

Y1 - 2013/10/2

N2 - A new, efficient, catalyst-free, one-pot, three-component method for the synthesis of 2-amino-substituted 7-amino-1,2,4-triazolo[1,5-a][1,3,5]triazines using 3,5-diamino-1,2,4-triazoles, cyanamide, and triethyl orthoformate is developed. The reaction proceeds smoothly under microwave-assisted heating. Advantages of the method include using easily available reagents, short reaction times, and operational simplicity.

AB - A new, efficient, catalyst-free, one-pot, three-component method for the synthesis of 2-amino-substituted 7-amino-1,2,4-triazolo[1,5-a][1,3,5]triazines using 3,5-diamino-1,2,4-triazoles, cyanamide, and triethyl orthoformate is developed. The reaction proceeds smoothly under microwave-assisted heating. Advantages of the method include using easily available reagents, short reaction times, and operational simplicity.

KW - Microwave-assisted synthesis

KW - Multicomponent reaction

KW - Purine isosters

KW - Triazines

KW - Triazoles

UR - https://www.scopus.com/pages/publications/84883464100

U2 - 10.1016/j.tetlet.2013.07.158

DO - 10.1016/j.tetlet.2013.07.158

M3 - Article

AN - SCOPUS:84883464100

SN - 0040-4039

VL - 54

SP - 5537

EP - 5540

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 40

ER -

A one-pot, three-component, microwave-promoted synthesis of 2-amino-substituted 7-amino-1,2,4-triazolo[1,5-a][1,3,5]triazines

Abstract

Keywords

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