A highly effective gene delivery vector - Hyperbranched poly(2-(dimethylamino)ethyl methacrylate) from in situ deactivation enhanced ATRP

Ben Newland; Hongyun Tai; Yu Zheng; Diego Velasco; Andrea Di Luca; Steven M. Howdle; Cameron Alexander; Wenxin Wang; Abhay Pandit

doi:10.1039/c0cc00439a

A highly effective gene delivery vector - Hyperbranched poly(2-(dimethylamino)ethyl methacrylate) from in situ deactivation enhanced ATRP

Ben Newland, Hongyun Tai, Yu Zheng, Diego Velasco, Andrea Di Luca, Steven M. Howdle, Cameron Alexander, Wenxin Wang, Abhay Pandit

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

88 Citations (Scopus)

Abstract

A hyperbranched 2-(dimethylamino)ethyl methacrylate (DMAEMA) based polymer has been synthesised by a one-pot in situ deactivation enhanced atom transfer radical polymerisation (DE-ATRP); it exhibits much higher transfection ability than linear poly(DMAEMA) and is comparable to the well known branched poly(ethylene imine) (PEI) and the SuperFect® dendrimer but with lower cytotoxicity.

Original language	English
Pages (from-to)	4698-4700
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	26
DOIs	https://doi.org/10.1039/c0cc00439a
Publication status	Published - 14 Jul 2010
Externally published	Yes

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10.1039/c0cc00439a

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title = "A highly effective gene delivery vector - Hyperbranched poly(2-(dimethylamino)ethyl methacrylate) from in situ deactivation enhanced ATRP",

abstract = "A hyperbranched 2-(dimethylamino)ethyl methacrylate (DMAEMA) based polymer has been synthesised by a one-pot in situ deactivation enhanced atom transfer radical polymerisation (DE-ATRP); it exhibits much higher transfection ability than linear poly(DMAEMA) and is comparable to the well known branched poly(ethylene imine) (PEI) and the SuperFect{\textregistered} dendrimer but with lower cytotoxicity.",

author = "Ben Newland and Hongyun Tai and Yu Zheng and Diego Velasco and \{Di Luca\}, Andrea and Howdle, \{Steven M.\} and Cameron Alexander and Wenxin Wang and Abhay Pandit",

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AU - Newland, Ben

AU - Tai, Hongyun

AU - Zheng, Yu

AU - Velasco, Diego

AU - Di Luca, Andrea

AU - Howdle, Steven M.

AU - Alexander, Cameron

AU - Wang, Wenxin

AU - Pandit, Abhay

PY - 2010/7/14

Y1 - 2010/7/14

N2 - A hyperbranched 2-(dimethylamino)ethyl methacrylate (DMAEMA) based polymer has been synthesised by a one-pot in situ deactivation enhanced atom transfer radical polymerisation (DE-ATRP); it exhibits much higher transfection ability than linear poly(DMAEMA) and is comparable to the well known branched poly(ethylene imine) (PEI) and the SuperFect® dendrimer but with lower cytotoxicity.

AB - A hyperbranched 2-(dimethylamino)ethyl methacrylate (DMAEMA) based polymer has been synthesised by a one-pot in situ deactivation enhanced atom transfer radical polymerisation (DE-ATRP); it exhibits much higher transfection ability than linear poly(DMAEMA) and is comparable to the well known branched poly(ethylene imine) (PEI) and the SuperFect® dendrimer but with lower cytotoxicity.

UR - https://www.scopus.com/pages/publications/77953896829

U2 - 10.1039/c0cc00439a

DO - 10.1039/c0cc00439a

M3 - Article

SN - 1359-7345

VL - 46

SP - 4698

EP - 4700

JO - Chemical Communications

JF - Chemical Communications

IS - 26

ER -

A highly effective gene delivery vector - Hyperbranched poly(2-(dimethylamino)ethyl methacrylate) from in situ deactivation enhanced ATRP

Abstract

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