A GTPase switch maintains CENP-A at centromeric chromatin

Lisa Prendergast; Kevin F. Sullivan

doi:10.1038/ncb1210-1128

A GTPase switch maintains CENP-A at centromeric chromatin

Lisa Prendergast
, Kevin F. Sullivan

Molecular Biosciences

University of Galway

Research output: Contribution to a Journal (Peer & Non Peer) › Short survey › peer-review

6 Citations (Scopus)

Abstract

The histone H3 variant CENP-A defines centromeric chromatin, but it has been unclear how CENP-A is stably maintained at centromeres. It has now been shown that the CENP-A licensing factor HsKNL2 and the small GTPases activating protein MgcRacGAP cooperate to promote the stability of newly loaded CENP-A at centromeres.

Original language	English
Pages (from-to)	1128-1130
Number of pages	3
Journal	Nature Cell Biology
Volume	12
Issue number	12
DOIs	https://doi.org/10.1038/ncb1210-1128
Publication status	Published - Dec 2010

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title = "A GTPase switch maintains CENP-A at centromeric chromatin",

abstract = "The histone H3 variant CENP-A defines centromeric chromatin, but it has been unclear how CENP-A is stably maintained at centromeres. It has now been shown that the CENP-A licensing factor HsKNL2 and the small GTPases activating protein MgcRacGAP cooperate to promote the stability of newly loaded CENP-A at centromeres.",

author = "Lisa Prendergast and Sullivan, \{Kevin F.\}",

year = "2010",

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doi = "10.1038/ncb1210-1128",

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volume = "12",

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journal = "Nature Cell Biology",

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T1 - A GTPase switch maintains CENP-A at centromeric chromatin

AU - Prendergast, Lisa

AU - Sullivan, Kevin F.

PY - 2010/12

Y1 - 2010/12

N2 - The histone H3 variant CENP-A defines centromeric chromatin, but it has been unclear how CENP-A is stably maintained at centromeres. It has now been shown that the CENP-A licensing factor HsKNL2 and the small GTPases activating protein MgcRacGAP cooperate to promote the stability of newly loaded CENP-A at centromeres.

AB - The histone H3 variant CENP-A defines centromeric chromatin, but it has been unclear how CENP-A is stably maintained at centromeres. It has now been shown that the CENP-A licensing factor HsKNL2 and the small GTPases activating protein MgcRacGAP cooperate to promote the stability of newly loaded CENP-A at centromeres.

UR - https://www.scopus.com/pages/publications/78649813418

U2 - 10.1038/ncb1210-1128

DO - 10.1038/ncb1210-1128

M3 - Short survey

SN - 1465-7392

VL - 12

SP - 1128

EP - 1130

JO - Nature Cell Biology

JF - Nature Cell Biology

IS - 12

ER -

A GTPase switch maintains CENP-A at centromeric chromatin

Abstract

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