TY - JOUR
T1 - A global genomic analysis of Salmonella Concord reveals lineages with high antimicrobial resistance in Ethiopia
AU - Cuypers, Wim L.
AU - Meysman, Pieter
AU - Weill, François Xavier
AU - Hendriksen, Rene S.
AU - Beyene, Getenet
AU - Wain, John
AU - Nair, Satheesh
AU - Chattaway, Marie A.
AU - Perez-Sepulveda, Blanca M.
AU - Ceyssens, Pieter Jan
AU - de Block, Tessa
AU - Lee, Winnie W.Y.
AU - Pardos de la Gandara, Maria
AU - Kornschober, Christian
AU - Moran-Gilad, Jacob
AU - Veldman, Kees T.
AU - Cormican, Martin
AU - Torpdahl, Mia
AU - Fields, Patricia I.
AU - Černý, Tomáš
AU - Hardy, Liselotte
AU - Tack, Bieke
AU - Mellor, Kate C.
AU - Thomson, Nicholas
AU - Dougan, Gordon
AU - Deborggraeve, Stijn
AU - Jacobs, Jan
AU - Laukens, Kris
AU - Van Puyvelde, Sandra
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/12
Y1 - 2023/12
N2 - Antimicrobial resistant Salmonella enterica serovar Concord (S. Concord) is known to cause severe gastrointestinal and bloodstream infections in patients from Ethiopia and Ethiopian adoptees, and occasional records exist of S. Concord linked to other countries. The evolution and geographical distribution of S. Concord remained unclear. Here, we provide a genomic overview of the population structure and antimicrobial resistance (AMR) of S. Concord by analysing genomes from 284 historical and contemporary isolates obtained between 1944 and 2022 across the globe. We demonstrate that S. Concord is a polyphyletic serovar distributed among three Salmonella super-lineages. Super-lineage A is composed of eight S. Concord lineages, of which four are associated with multiple countries and low levels of AMR. Other lineages are restricted to Ethiopia and horizontally acquired resistance to most antimicrobials used for treating invasive Salmonella infections in low- and middle-income countries. By reconstructing complete genomes for 10 representative strains, we demonstrate the presence of AMR markers integrated in structurally diverse IncHI2 and IncA/C2 plasmids, and/or the chromosome. Molecular surveillance of pathogens such as S. Concord supports the understanding of AMR and the multi-sector response to the global AMR threat. This study provides a comprehensive baseline data set essential for future molecular surveillance.
AB - Antimicrobial resistant Salmonella enterica serovar Concord (S. Concord) is known to cause severe gastrointestinal and bloodstream infections in patients from Ethiopia and Ethiopian adoptees, and occasional records exist of S. Concord linked to other countries. The evolution and geographical distribution of S. Concord remained unclear. Here, we provide a genomic overview of the population structure and antimicrobial resistance (AMR) of S. Concord by analysing genomes from 284 historical and contemporary isolates obtained between 1944 and 2022 across the globe. We demonstrate that S. Concord is a polyphyletic serovar distributed among three Salmonella super-lineages. Super-lineage A is composed of eight S. Concord lineages, of which four are associated with multiple countries and low levels of AMR. Other lineages are restricted to Ethiopia and horizontally acquired resistance to most antimicrobials used for treating invasive Salmonella infections in low- and middle-income countries. By reconstructing complete genomes for 10 representative strains, we demonstrate the presence of AMR markers integrated in structurally diverse IncHI2 and IncA/C2 plasmids, and/or the chromosome. Molecular surveillance of pathogens such as S. Concord supports the understanding of AMR and the multi-sector response to the global AMR threat. This study provides a comprehensive baseline data set essential for future molecular surveillance.
UR - https://www.scopus.com/pages/publications/85161863342
U2 - 10.1038/s41467-023-38902-x
DO - 10.1038/s41467-023-38902-x
M3 - Article
C2 - 37316492
AN - SCOPUS:85161863342
SN - 2041-1723
VL - 14
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 3517
ER -