A D-alanine aminotransferase S180F substitution confers resistance to β-chloro-D-alanine in Staphylococcus aureus via antibiotic inactivation

Rakesh Roy; Yahani P. Jayasinghe; Sasmita Panda; Merve S. Zeden; Vinai C. Thomas; Donald R. Ronning; James P. O’Gara

doi:10.1101/2025.08.17.668425

A D-alanine aminotransferase S180F substitution confers resistance to β-chloro-D-alanine in Staphylococcus aureus via antibiotic inactivation

Rakesh Roy
, Yahani P. Jayasinghe
, Sasmita Panda
, Merve S. Zeden
, Vinai C. Thomas
, Donald R. Ronning
, James P. O’Gara

Research output: Other contribution (Published) › Other contribution

Original language	English
DOIs	https://doi.org/10.1101/2025.08.17.668425
Publication status	Published - 18 Aug 2025

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10.1101/2025.08.17.668425

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title = "A D-alanine aminotransferase S180F substitution confers resistance to β-chloro-D-alanine in Staphylococcus aureus via antibiotic inactivation",

author = "Rakesh Roy and Jayasinghe, \{Yahani P.\} and Sasmita Panda and Zeden, \{Merve S.\} and Thomas, \{Vinai C.\} and Ronning, \{Donald R.\} and O{\textquoteright}Gara, \{James P.\}",

year = "2025",

month = aug,

day = "18",

doi = "10.1101/2025.08.17.668425",

language = "English",

type = "Other",

}

TY - GEN

T1 - A D-alanine aminotransferase S180F substitution confers resistance to β-chloro-D-alanine in Staphylococcus aureus via antibiotic inactivation

AU - Roy, Rakesh

AU - Jayasinghe, Yahani P.

AU - Panda, Sasmita

AU - Zeden, Merve S.

AU - Thomas, Vinai C.

AU - Ronning, Donald R.

AU - O’Gara, James P.

PY - 2025/8/18

Y1 - 2025/8/18

UR - https://doi.org/10.1101/2025.08.17.668425

U2 - 10.1101/2025.08.17.668425

DO - 10.1101/2025.08.17.668425

M3 - Other contribution

ER -

A D-alanine aminotransferase S180F substitution confers resistance to β-chloro-D-alanine in Staphylococcus aureus via antibiotic inactivation

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