A Cu(ii) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights

D. Montagner; B. Fresch; K. Browne; V. Gandin; A. Erxleben

doi:10.1039/C6CC08100B

A Cu(ii) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights

D. Montagner
, B. Fresch
, K. Browne
, V. Gandin
, A. Erxleben

Cellular & Molecular Medicine

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

31 Citations (Scopus)

Abstract

A new Cu-based anticancer metallodrug which targets the translocator protein is reported. [CuBr₂(TZ6)] elicits a remarkable in vitro cytotoxicity in sensitive and multidrug resistant cell lines and induces a 98% reduction of tumor mass in a murine tumor model. Target binding was studied by experimental and computational methods.

Original language	English
Pages (from-to)	134-137
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	1
DOIs	https://doi.org/10.1039/C6CC08100B
Publication status	Published - 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1039/C6CC08100B

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title = "A Cu(ii) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights",

abstract = "A new Cu-based anticancer metallodrug which targets the translocator protein is reported. [CuBr2(TZ6)] elicits a remarkable in vitro cytotoxicity in sensitive and multidrug resistant cell lines and induces a 98\% reduction of tumor mass in a murine tumor model. Target binding was studied by experimental and computational methods.",

author = "D. Montagner and B. Fresch and K. Browne and V. Gandin and A. Erxleben",

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year = "2017",

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T1 - A Cu(ii) complex targeting the translocator protein

T2 - in vitro and in vivo antitumor potential and mechanistic insights

AU - Montagner, D.

AU - Fresch, B.

AU - Browne, K.

AU - Gandin, V.

AU - Erxleben, A.

PY - 2017

Y1 - 2017

N2 - A new Cu-based anticancer metallodrug which targets the translocator protein is reported. [CuBr2(TZ6)] elicits a remarkable in vitro cytotoxicity in sensitive and multidrug resistant cell lines and induces a 98% reduction of tumor mass in a murine tumor model. Target binding was studied by experimental and computational methods.

AB - A new Cu-based anticancer metallodrug which targets the translocator protein is reported. [CuBr2(TZ6)] elicits a remarkable in vitro cytotoxicity in sensitive and multidrug resistant cell lines and induces a 98% reduction of tumor mass in a murine tumor model. Target binding was studied by experimental and computational methods.

UR - https://www.scopus.com/pages/publications/85006959940

U2 - 10.1039/C6CC08100B

DO - 10.1039/C6CC08100B

M3 - Article

SN - 1359-7345

VL - 53

SP - 134

EP - 137

JO - Chemical Communications

JF - Chemical Communications

IS - 1

ER -

A Cu(ii) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights

Abstract

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