TY - JOUR
T1 - A comparison of systematic stenting and conventional balloon angioplasty during primary percutaneous transluminal coronary angioplasty for acute myocardial infarction
AU - Maillard, Luc
AU - Hamon, Martial
AU - Khalife, Khalife
AU - Steg, Philippe Gabriel
AU - Beygui, Farzin
AU - Guermonprez, Jean Leon
AU - Spaulding, Christian M.
AU - Boulenc, Jean Marc
AU - Lipiecki, Janusz
AU - Lafont, Antoine
AU - Brunel, Philippe
AU - Grollier, Gilles
AU - Koning, Rene
AU - Coste, Pierre
AU - Favereau, Xavier
AU - Lancelin, Bernard
AU - Van Belle, Eric
AU - Serruys, Patrick
AU - Monassier, Jean Pierre
AU - Raynaud, Philippe
PY - 2000/6
Y1 - 2000/6
N2 - Objectives. In a multicenter, randomized trial, systematic stenting using the Wiktor stent was compared to conventional balloon angioplasty with provisional stenting for the treatment of acute myocardial infarction (AMI). Background. Primary angioplasty in AMI is limited by in-hospital recurrent ischemia and a high restenosis rate. Methods. A total of 211 patients with AMI <12 h from symptom onset, with an occluded native coronary artery, were randomly assigned to systematic stenting (n = 101) or balloon angioplasty (n = 110). The primary end point was the binary six-month restenosis rate determined by core laboratory quantitative angiographic analysis. Results. Angiographic success (Thrombolysis in Myocardial Infarction [TIMI] flow grade 3 and residual diameter stenosis <50%) was achieved in 86% of the patients in the stent group and in 82.7% of those in the balloon angioplasty group (p = 0.5). Compared with the 3% cross-over in the stent group, cross-over to stenting was required in 36.4% of patients in the balloon angioplasty group (p = 0.0001). Six-month binary restenosis (≥50% residual stenosis) rates were 25.3% in the stent group and 39.6% in the balloon angioplasty group (p = 0.04). At six months, the event-free survival rates were 81.2% in the stent group and 72.7% in the balloon angioplasty group (p = 0.14), and the repeat revascularization rates were 16.8% and 26.4%, respectively (p = 0.1). At one year, the event-free survival rates were 80.2% in the stent group and 71.8% in the balloon angioplasty group (p = 0.16), and the repeat revascularization rates were 17.8% and 28.2%, respectively (p = 0.1). Conclusions. In the setting of primary angioplasty for AMI, as compared with a strategy of conventional balloon angioplasty, systematic stenting using the Wiktor stent results in lower rates of angiographic restenosis. (C) 2000 by the American College of Cardiology.
AB - Objectives. In a multicenter, randomized trial, systematic stenting using the Wiktor stent was compared to conventional balloon angioplasty with provisional stenting for the treatment of acute myocardial infarction (AMI). Background. Primary angioplasty in AMI is limited by in-hospital recurrent ischemia and a high restenosis rate. Methods. A total of 211 patients with AMI <12 h from symptom onset, with an occluded native coronary artery, were randomly assigned to systematic stenting (n = 101) or balloon angioplasty (n = 110). The primary end point was the binary six-month restenosis rate determined by core laboratory quantitative angiographic analysis. Results. Angiographic success (Thrombolysis in Myocardial Infarction [TIMI] flow grade 3 and residual diameter stenosis <50%) was achieved in 86% of the patients in the stent group and in 82.7% of those in the balloon angioplasty group (p = 0.5). Compared with the 3% cross-over in the stent group, cross-over to stenting was required in 36.4% of patients in the balloon angioplasty group (p = 0.0001). Six-month binary restenosis (≥50% residual stenosis) rates were 25.3% in the stent group and 39.6% in the balloon angioplasty group (p = 0.04). At six months, the event-free survival rates were 81.2% in the stent group and 72.7% in the balloon angioplasty group (p = 0.14), and the repeat revascularization rates were 16.8% and 26.4%, respectively (p = 0.1). At one year, the event-free survival rates were 80.2% in the stent group and 71.8% in the balloon angioplasty group (p = 0.16), and the repeat revascularization rates were 17.8% and 28.2%, respectively (p = 0.1). Conclusions. In the setting of primary angioplasty for AMI, as compared with a strategy of conventional balloon angioplasty, systematic stenting using the Wiktor stent results in lower rates of angiographic restenosis. (C) 2000 by the American College of Cardiology.
UR - http://www.scopus.com/inward/record.url?scp=0034074865&partnerID=8YFLogxK
U2 - 10.1016/S0735-1097(00)00612-4
DO - 10.1016/S0735-1097(00)00612-4
M3 - Article
C2 - 10841218
AN - SCOPUS:0034074865
SN - 0735-1097
VL - 35
SP - 1729
EP - 1736
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 7
ER -