A candidate gene analysis of two phospholipase genes that map to the chromosome 15Q15.1-15.3 region associated with reading disability

D. W. Morris; L. Robinson; D. Turic; M. Duke; M. J. Owen; M. C. O'Donovan; J. Willia

A candidate gene analysis of two phospholipase genes that map to the chromosome 15Q15.1-15.3 region associated with reading disability

D. W. Morris
, L. Robinson
, D. Turic
, M. Duke
, M. J. Owen
, M. C. O'Donovan
, J. Willia

Cardiff University

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

Abstract

We have identified a region associated with dyslexia/reading disability (RD) on chromosome 15q by linkage disequilibrium mapping using microsatellite markers (Morris et. al. (2000) Hum Mol Genet 9 (5): 843-848). Two phospholipase genes map to our associated region. They are phospholipase C beta-2 (PLCB2) and phospholipase A2, group IVB (cytosolic; PLA2G4B). Evidence supports an association between increased levels of cytosolic phospholipase A2 and dyslexia in adults. We have completed mutation detection analysis of PLCB2 and PLA2G4B and genotyped 14 SNPs in pooled samples of 143 RD cases and 171 controls. Two SNPs in PLA2G4B show evidence of association with RD (P < 0.05) by case control analysis. We are currently analysing these SNPs in a family-based association sample (178 RD trios).

Original language	English
Pages (from-to)	586-587
Number of pages	2
Journal	American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume	105
Issue number	7
Publication status	Published - 8 Oct 2001
Externally published	Yes

Cite this

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title = "A candidate gene analysis of two phospholipase genes that map to the chromosome 15Q15.1-15.3 region associated with reading disability",

abstract = "We have identified a region associated with dyslexia/reading disability (RD) on chromosome 15q by linkage disequilibrium mapping using microsatellite markers (Morris et. al. (2000) Hum Mol Genet 9 (5): 843-848). Two phospholipase genes map to our associated region. They are phospholipase C beta-2 (PLCB2) and phospholipase A2, group IVB (cytosolic; PLA2G4B). Evidence supports an association between increased levels of cytosolic phospholipase A2 and dyslexia in adults. We have completed mutation detection analysis of PLCB2 and PLA2G4B and genotyped 14 SNPs in pooled samples of 143 RD cases and 171 controls. Two SNPs in PLA2G4B show evidence of association with RD (P < 0.05) by case control analysis. We are currently analysing these SNPs in a family-based association sample (178 RD trios).",

author = "Morris, \{D. W.\} and L. Robinson and D. Turic and M. Duke and Owen, \{M. J.\} and O'Donovan, \{M. C.\} and J. Willia",

year = "2001",

month = oct,

day = "8",

language = "English",

volume = "105",

pages = "586--587",

journal = "American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics",

issn = "1552-4841",

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number = "7",

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A candidate gene analysis of two phospholipase genes that map to the chromosome 15Q15.1-15.3 region associated with reading disability. / Morris, D. W.; Robinson, L.; Turic, D. et al.
In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Vol. 105, No. 7, 08.10.2001, p. 586-587.

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

TY - JOUR

T1 - A candidate gene analysis of two phospholipase genes that map to the chromosome 15Q15.1-15.3 region associated with reading disability

AU - Morris, D. W.

AU - Robinson, L.

AU - Turic, D.

AU - Duke, M.

AU - Owen, M. J.

AU - O'Donovan, M. C.

AU - Willia, J.

PY - 2001/10/8

Y1 - 2001/10/8

N2 - We have identified a region associated with dyslexia/reading disability (RD) on chromosome 15q by linkage disequilibrium mapping using microsatellite markers (Morris et. al. (2000) Hum Mol Genet 9 (5): 843-848). Two phospholipase genes map to our associated region. They are phospholipase C beta-2 (PLCB2) and phospholipase A2, group IVB (cytosolic; PLA2G4B). Evidence supports an association between increased levels of cytosolic phospholipase A2 and dyslexia in adults. We have completed mutation detection analysis of PLCB2 and PLA2G4B and genotyped 14 SNPs in pooled samples of 143 RD cases and 171 controls. Two SNPs in PLA2G4B show evidence of association with RD (P < 0.05) by case control analysis. We are currently analysing these SNPs in a family-based association sample (178 RD trios).

AB - We have identified a region associated with dyslexia/reading disability (RD) on chromosome 15q by linkage disequilibrium mapping using microsatellite markers (Morris et. al. (2000) Hum Mol Genet 9 (5): 843-848). Two phospholipase genes map to our associated region. They are phospholipase C beta-2 (PLCB2) and phospholipase A2, group IVB (cytosolic; PLA2G4B). Evidence supports an association between increased levels of cytosolic phospholipase A2 and dyslexia in adults. We have completed mutation detection analysis of PLCB2 and PLA2G4B and genotyped 14 SNPs in pooled samples of 143 RD cases and 171 controls. Two SNPs in PLA2G4B show evidence of association with RD (P < 0.05) by case control analysis. We are currently analysing these SNPs in a family-based association sample (178 RD trios).

UR - https://www.scopus.com/pages/publications/33749113604

M3 - Article

AN - SCOPUS:33749113604

SN - 1552-4841

VL - 105

SP - 586

EP - 587

JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

IS - 7

ER -

A candidate gene analysis of two phospholipase genes that map to the chromosome 15Q15.1-15.3 region associated with reading disability

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