53BP1: function and mechanisms of focal recruitment.: Function and mechanisms of focal recruitment

Noel F Lowndes; Muriel Grenon

doi:10.1042/BST0370897

53BP1: function and mechanisms of focal recruitment. Function and mechanisms of focal recruitment

University of Galway

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

115 Citations (Scopus)

Abstract

53BP1 (p53-binding protein 1) is classified as a mediator adaptor of the DNA-damage response, and is recruited to nuclear structures termed foci following genotoxic insult. In the present paper, we review the functions of 53BP1 in DNA-damage checkpoint activation and DNA repair, and the mechanisms of its recruitment and activation following DNA damage. We focus in particular on the role of covalent histone modifications in this process.

Original language	English (Ireland)
Pages (from-to)	897-904
Number of pages	8
Journal	Biochemical Society Transactions
Volume	37
Issue number	Pt 4
DOIs	https://doi.org/10.1042/BST0370897
Publication status	Published - 1 Aug 2009

Keywords

Dot1
Histone 2AX (H2AX)
Histone methylation
Mediator of DNA-damage checkpoint 1 (MDC1)
P53-binding protein 1 (53BP1)
Rad9

Authors (Note for portal: view the doc link for the full list of authors)

Authors
FitzGerald JE, Grenon M, Lowndes NF

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1042/BST0370897

Cite this

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KW - Mediator of DNA-damage checkpoint 1 (MDC1)

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