53BP1: function and mechanisms of focal recruitment

Muriel Grenon; Noel F Lowndes

doi:10.1042/BST0370897

53BP1: function and mechanisms of focal recruitment

Research output: Chapter in Book or Conference Publication/Proceeding › Conference Publication › peer-review

Abstract

53BP1 (p53-binding protein 1) is classified as a mediator adaptor of the DNA-damage response, and is recruited to nuclear structures termed foci following genotoxic insult. In the present paper, we review the functions of S3BP1 in DNA-damage checkpoint activation and DNA repair, and the mechanisms of its recruitment and activation following DNA damage. We focus in particular on the role of covalent histone modifications in this process.

Original language	English (Ireland)
Title of host publication	BIOCHEMICAL SOCIETY TRANSACTIONS
Publisher	PORTLAND PRESS LTD
Number of pages	7
Volume	37
ISBN (Electronic)	0300-5127
ISBN (Print)	0300-5127
DOIs	https://doi.org/10.1042/BST0370897
Publication status	Published - 1 Aug 2009

Authors (Note for portal: view the doc link for the full list of authors)

Authors
FitzGerald, JE;Grenon, M;Lowndes, NF

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10.1042/BST0370897

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title = "53BP1: function and mechanisms of focal recruitment",

abstract = "53BP1 (p53-binding protein 1) is classified as a mediator adaptor of the DNA-damage response, and is recruited to nuclear structures termed foci following genotoxic insult. In the present paper, we review the functions of S3BP1 in DNA-damage checkpoint activation and DNA repair, and the mechanisms of its recruitment and activation following DNA damage. We focus in particular on the role of covalent histone modifications in this process.",

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AU - Lowndes, Noel F

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N2 - 53BP1 (p53-binding protein 1) is classified as a mediator adaptor of the DNA-damage response, and is recruited to nuclear structures termed foci following genotoxic insult. In the present paper, we review the functions of S3BP1 in DNA-damage checkpoint activation and DNA repair, and the mechanisms of its recruitment and activation following DNA damage. We focus in particular on the role of covalent histone modifications in this process.

AB - 53BP1 (p53-binding protein 1) is classified as a mediator adaptor of the DNA-damage response, and is recruited to nuclear structures termed foci following genotoxic insult. In the present paper, we review the functions of S3BP1 in DNA-damage checkpoint activation and DNA repair, and the mechanisms of its recruitment and activation following DNA damage. We focus in particular on the role of covalent histone modifications in this process.

U2 - 10.1042/BST0370897

DO - 10.1042/BST0370897

M3 - Conference Publication

SN - 0300-5127

VL - 37

BT - BIOCHEMICAL SOCIETY TRANSACTIONS

PB - PORTLAND PRESS LTD

ER -

53BP1: function and mechanisms of focal recruitment

Abstract

Authors (Note for portal: view the doc link for the full list of authors)

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