3D Cell Culture Systems for the Development of Neural Interfaces

Omaer Syed; Chris Chapman; Catalina Vallejo-Giraldo; Martina Genta; Josef Goding; Emmanuel Kanelos; Rylie Green

doi:10.1007/978-3-030-41854-0_8

3D Cell Culture Systems for the Development of Neural Interfaces

Omaer Syed, Chris Chapman, Catalina Vallejo-Giraldo, Martina Genta, Josef Goding, Emmanuel Kanelos, Rylie Green

Imperial College London

Research output: Chapter in Book or Conference Publication/Proceeding › Chapter › peer-review

1 Citation (Scopus)

Abstract

Neural interface research and development covers a wide spectrum of topics, spanning basic neuroscience to design of implantable devices. In vitro studies have been an integral part of this research and form the basis of regulated preclinical studies. Historically, 2D cell cultures have provided substantial data on neural interfaces; however, these have inherent limitations. Critically, they do not recapitulate essential features of the in vivo environment, having limited cell-cell and cell-ECM interactions. This has driven the development of 3D cell culture models. Three approaches to 3D models are discussed, encompassing explant/ex vivo models, cell-only approaches, and biomaterials and scaffolds. Each approach offers advantages and limitations, which recommend them to specific applications. These issues are discussed with focus on their contributions to neural interface research.

Original language	English
Title of host publication	Neural Interface Engineering
Subtitle of host publication	Linking the Physical World and the Nervous System
Publisher	Springer International Publishing
Pages	201-236
Number of pages	36
ISBN (Electronic)	9783030418540
ISBN (Print)	9783030418533
DOIs	https://doi.org/10.1007/978-3-030-41854-0_8
Publication status	Published - 1 Jan 2020
Externally published	Yes

Keywords

3D
Cell Culture
Interface
Neural

Access to Document

10.1007/978-3-030-41854-0_8

Cite this

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AU - Goding, Josef

AU - Kanelos, Emmanuel

AU - Green, Rylie

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3D Cell Culture Systems for the Development of Neural Interfaces

Abstract

Keywords

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