2-(Fluoromethyl)-4,7-dimethoxy-1-methyl-1H-benzimidazole

Patrick Kielty; Pau Farràs; Dennis A. Smith; Fawaz Aldabbagh

doi:10.3390/M1129

2-(Fluoromethyl)-4,7-dimethoxy-1-methyl-1H-benzimidazole

Patrick Kielty
, Pau Farràs
, Dennis A. Smith
, Fawaz Aldabbagh

Sustainable World

Research output: Contribution to a Journal (Peer & Non Peer) › Comment/debate

5 Citations (Scopus)

Abstract

Selectfluor (1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)) substitutes the TEMPO free radical with fluorine on 4,7-dimethoxy-1-methyl-2-{[(2,2,6,6-tetramethylpiperidin-1-yl)oxy]methyl}-1H-benzimidazole to give the title compound in a 77% yield. A mechanism is proposed for the formation of this novel methylene fluoride.

Original language	English
Article number	M1129
Journal	MolBank
Volume	2020
Issue number	2
DOIs	https://doi.org/10.3390/M1129
Publication status	Published - Jun 2020

Keywords

Fluorine
Nitrogen heterocycles
Nitroxide
Radicals
Selectfluor
TEMPO

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10.3390/M1129

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@article{7088f590b78e469cab1b7b608457ef0a,

title = "2-(Fluoromethyl)-4,7-dimethoxy-1-methyl-1H-benzimidazole",

abstract = "Selectfluor (1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)) substitutes the TEMPO free radical with fluorine on 4,7-dimethoxy-1-methyl-2-\{[(2,2,6,6-tetramethylpiperidin-1-yl)oxy]methyl\}-1H-benzimidazole to give the title compound in a 77\% yield. A mechanism is proposed for the formation of this novel methylene fluoride.",

keywords = "Fluorine, Nitrogen heterocycles, Nitroxide, Radicals, Selectfluor, TEMPO",

author = "Patrick Kielty and Pau Farr{\`a}s and Smith, \{Dennis A.\} and Fawaz Aldabbagh",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = jun,

doi = "10.3390/M1129",

language = "English",

volume = "2020",

journal = "MolBank",

issn = "1422-8599",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "2",

}

TY - JOUR

T1 - 2-(Fluoromethyl)-4,7-dimethoxy-1-methyl-1H-benzimidazole

AU - Kielty, Patrick

AU - Farràs, Pau

AU - Smith, Dennis A.

AU - Aldabbagh, Fawaz

PY - 2020/6

Y1 - 2020/6

N2 - Selectfluor (1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)) substitutes the TEMPO free radical with fluorine on 4,7-dimethoxy-1-methyl-2-{[(2,2,6,6-tetramethylpiperidin-1-yl)oxy]methyl}-1H-benzimidazole to give the title compound in a 77% yield. A mechanism is proposed for the formation of this novel methylene fluoride.

AB - Selectfluor (1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)) substitutes the TEMPO free radical with fluorine on 4,7-dimethoxy-1-methyl-2-{[(2,2,6,6-tetramethylpiperidin-1-yl)oxy]methyl}-1H-benzimidazole to give the title compound in a 77% yield. A mechanism is proposed for the formation of this novel methylene fluoride.

KW - Fluorine

KW - Nitrogen heterocycles

KW - Nitroxide

KW - Radicals

KW - Selectfluor

KW - TEMPO

UR - https://www.scopus.com/pages/publications/85084485806

U2 - 10.3390/M1129

DO - 10.3390/M1129

M3 - Comment/debate

SN - 1422-8599

VL - 2020

JO - MolBank

JF - MolBank

IS - 2

M1 - M1129

ER -

2-(Fluoromethyl)-4,7-dimethoxy-1-methyl-1H-benzimidazole

Abstract

Keywords

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