@article{15c47a972fb84353b4471082037ec32f,
title = "π-HuB: the proteomic navigator of the human body",
abstract = "The human body contains trillions of cells, classified into specific cell types, with diverse morphologies and functions. In addition, cells of the same type can assume different states within an individual{\textquoteright}s body during their lifetime. Understanding the complexities of the proteome in the context of a human organism and its many potential states is a necessary requirement to understanding human biology, but these complexities can neither be predicted from the genome, nor have they been systematically measurable with available technologies. Recent advances in proteomic technology and computational sciences now provide opportunities to investigate the intricate biology of the human body at unprecedented resolution and scale. Here we introduce a big-science endeavour called π-HuB (proteomic navigator of the human body). The aim of the π-HuB project is to (1) generate and harness multimodality proteomic datasets to enhance our understanding of human biology; (2) facilitate disease risk assessment and diagnosis; (3) uncover new drug targets; (4) optimize appropriate therapeutic strategies; and (5) enable intelligent healthcare, thereby ushering in a new era of proteomics-driven phronesis medicine. This ambitious mission will be implemented by an international collaborative force of multidisciplinary research teams worldwide across academic, industrial and government sectors.",
author = "\{The π-HuB Consortium\} and Fuchu He and Ruedi Aebersold and Baker, \{Mark S.\} and Xiuwu Bian and Xiaochen Bo and Chan, \{Daniel W.\} and Cheng Chang and Luonan Chen and Xiangmei Chen and Chen, \{Yu Ju\} and Heping Cheng and Collins, \{Ben C.\} and Fernando Corrales and J{\"u}rgen Cox and Weinan E and \{Van Eyk\}, \{Jennifer E.\} and Jia Fan and Pouya Faridi and Daniel Figeys and Gao, \{George Fu\} and Wen Gao and Gao, \{Zu Hua\} and Keisuke Goda and Goh, \{Wilson Wen Bin\} and Dongfeng Gu and Changjiang Guo and Tiannan Guo and Yuezhong He and Heck, \{Albert J.R.\} and Henning Hermjakob and Tony Hunter and Iyer, \{Narayanan Gopalakrishna\} and Ying Jiang and Jimenez, \{Connie R.\} and Lokesh Joshi and Kelleher, \{Neil L.\} and Ming Li and Yang Li and Qingsong Lin and Liu, \{Cui Hua\} and Fan Liu and Liu, \{Guang Hui\} and Yansheng Liu and Zhihua Liu and Low, \{Teck Yew\} and Ben Lu and Matthias Mann and Anming Meng and Moritz, \{Robert L.\} and Edouard Nice and Guang Ning and Omenn, \{Gilbert S.\} and Overall, \{Christopher M.\} and Giuseppe Palmisano and Yaojin Peng and Charles Pineau and Poon, \{Terence Chuen Wai\} and Purcell, \{Anthony W.\} and Jie Qiao and Reddel, \{Roger R.\} and Robinson, \{Phillip J.\} and Paola Roncada and Chris Sander and Jiahao Sha and Erwei Song and Sanjeeva Srivastava and Aihua Sun and Sze, \{Siu Kwan\} and Chao Tang and Liujun Tang and Ruijun Tian and Vizca{\'i}no, \{Juan Antonio\} and Chanjuan Wang and Chen Wang and Xiaowen Wang and Xinxing Wang and Yan Wang and Tobias Weiss and Mathias Wilhelm and Robert Winkler and Bernd Wollscheid and Limsoon Wong and Linhai Xie and Wei Xie and Tao Xu and Tianhao Xu and Liying Yan and Jing Yang and Xiao Yang and John Yates and Tao Yun and Qiwei Zhai and Bing Zhang and Hui Zhang and Lihua Zhang and Lingqiang Zhang and Pingwen Zhang and Yukui Zhang and Zheng, \{Yu Zi\} and Qing Zhong",
note = "Publisher Copyright: {\textcopyright} Springer Nature Limited 2024.",
year = "2024",
month = dec,
day = "12",
doi = "10.1038/s41586-024-08280-5",
language = "English",
volume = "636",
pages = "322--331",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Research",
number = "8042",
}