Research output per year
Research output per year
Personal profile
Biography
Dr. Fleming is an Associate Professor in the School of Medicine, at the University of Galway. He also leads the Systems Biochemistry Group within the Digital Metabolic Twin Centre (www.digitalmetabolictwin.org) at the University of Galway. The Systems Biochemistry Group is an interdisciplinary research group of computational and mathematical biologists. Dr. Fleming coordinates the Horizon Europe project "Reconstruction and Computational Modelling for Inherited Metabolic Diseases" www.recon4imd.org (2023-2027).
Research Interests
Fundamental interest is to develop scalable mathematical and numerical analysis techniques that increase the predictive fidelity of biomolecular network models, by incorporating physicochemical constraints, motivated by optimality principles. Applied interest is in the aetiopathogenesis and amelioration of inherited metabolic and neurodegenerative diseases.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD
Accepting PhD Students
- Accepting PhD Students
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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A genome-scale metabolic reconstruction resource of 247,092 diverse human microbes spanning multiple continents, age groups, and body sites
Heinken, A., Hulshof, T. O., Nap, B., Martinelli, F., Basile, A., O'Brolchain, A., O'Sullivan, N. F., Gallagher, C., Magee, E., McDonagh, F., Lalor, I., Bergin, M., Evans, P., Daly, R., Farrell, R., Delaney, R. M., Hill, S., McAuliffe, S. R., Kilgannon, T. & Fleming, R. M. T. & 2 others, , 19 Feb 2025, In: Cell Systems. 16, 2, 101196.Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review
Open Access1 Citation (Scopus) -
Identification of metabolites reproducibly associated with Parkinson’s Disease via meta-analysis and computational modelling
Luo, X., Liu, Y., Balck, A., Klein, C. & Fleming, R. M. T., Dec 2024, In: npj Parkinson's Disease. 10, 1, 126.Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review
Open Access8 Citations (Scopus) -
Integration of proteomic data with genome-scale metabolic models: A methodological overview
Zare, F. & Fleming, R. M. T., Oct 2024, In: Protein Science. 33, 10, e5150.Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review
Open Access1 Citation (Scopus) -
Cardinality optimization in constraint-based modelling: application to human metabolism
Fleming, R. M. T., Haraldsdottir, H. S., Minh, L. H., Vuong, P. T., Hankemeier, T. & Thiele, I., 1 Sep 2023, In: Bioinformatics. 39, 9, btad450.Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review
Open Access2 Citations (Scopus) -
Genome-scale metabolic reconstruction of 7,302 human microbes for personalised medicine
Fleming, R., 1 Jan 2023, In: Nature Biotechnology.Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review
Activities
- 5 Current Postgraduates (Research) Supervised
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Xi Luo
Fleming, R. (Primary Supervisor)
2024Activity: Other › Current Postgraduates (Research) Supervised
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Yanjun Liu
Fleming, R. (Primary Supervisor)
2024Activity: Other › Current Postgraduates (Research) Supervised
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Farid Zare
Fleming, R. (Primary Supervisor)
2024Activity: Other › Current Postgraduates (Research) Supervised
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Hadjar Rahou
Fleming, R. (Primary Supervisor)
2024Activity: Other › Current Postgraduates (Research) Supervised
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Saleh Alwer
Fleming, R. (Primary Supervisor)
2024Activity: Other › Current Postgraduates (Research) Supervised