Accepting PhD Students

PhD projects

The DNA Damage Response laboratory focuses on elucidation of the responses of primary and transformed human cells, including stem cells, to DNA damage by ultraviolet light, ionising radiation and platinum-based chemotherapeutic drugs.
Projects include:
a. characterisation of protein phosphorylation by DNA damage-activated PIK kinases; b. investigation of the role of the POLH gene product, DNA polymerase eta, in replication of damaged DNA and genome stability in cells from patients with the skin cancer-prone disease xeroderma pigmentosum variant;
c. elucidation of the response of primary normal human melanocytes to DNA damage by long-wavelength UVA radiation, a major risk factor for melanoma development.
d. collaborative research with Dr. Fawaz Aldabbagh (School of Chemistry, NUI Galway) focuses on the effects of novel mitomycin C-related agents on cancer cell viability.

Calculated based on number of publications stored in Pure and citations from Scopus

Personal profile

Biography

Dr. Carty received his Ph.D. degree from the Department of Biochemistry at the National University of Ireland, Galway, in 1986. He then obtained a Fogarty International fellowship to carry out post-doctoral research at the National Institutes of Health at Bethesda, MD, in the area of DNA replication in mammalian cells. From 1991, at the Department of Environmental Health at the University of Cincinnati Medical School, Dr. Carty carried out research on cellular responses to agents that damage DNA, especially ultraviolet light, a major cause of skin cancer. Dr. Carty took up a position as a College Lecturer in the Department of Biochemistry at the National University of Ireland, Galway in 2000.  He is currently Senior Lecturer and Head of Biochemistry, School of Natural Sciences, NUI Galway.Dr. Carty is head of the DNA Damage Response laboratory in the Centre for Chromosome Biology, NUI Galway.  His research group focuses on how the loss of genome stability contributes to cancer development, and on the molecular responses of human cells to UV light, and to DNA damaging agents such as cisplatin that are used in cancer therapy.  In collaboration with Prof. Frank Barry (Regenerative Medicine Institute)  the responses of human mesenchymal stem cells to cisplatin and ionising radiation have also been characterised.  In addition, the response of human cancer cell lines to novel mitomycin C-related chemical compounds is being investigated in an ongoing collaboration with Dr. Fawaz Aldabbagh (School of Chemistry, NUI Galway).

Research Interests

Responses of human cells to DNA damage, in particular following expousre to ultraviolet radiation and platinum-based chemotherapeutic drugs; Genome instability; the POLH gene and DNA polymerase eta; PIKK kinases and Replication protein A phosphorylation after DNA damage; DNA damage responses in mesenchymal stem cells; responses to long wavelength UVA radiation in melanocytes.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

B.Sc., Ph.D.

Accepting PhD Students

  • Accepting PhD Students

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