Personal profile
Biography
I'm a Cypriot scientist with a passion for microbiology that brought me to Imperial College London for my BSc Microbiology degree. I completed my Master of Research in Bacterial Pathogenesis and Infection and pursued my PhD in the Gründling lab investigating the requirement of c-di-AMP for the growth of Staphylococcus aureus. I moved to Ireland in 2020, for my postdoc in the O’Gara lab at University of Galway to integrate molecular microbiology with antimicrobial resistance (AMR) research. I am an Assistant Professor/Lecturer in Microbiology in the University of Galway, and I hold a Research Ireland (SFI-IRC) Pathway Fellowship. I am also a collaborator partner on a recent grant awarded by the European Union (EU) Joint Programming Initiative on Antimicrobial Resistance (JPIAMR) Interventions. My research group focuses on understanding and manipulating Staphylococcal metabolism whilst developing targeted antisense oligonucleotide therapeutics against AMR in ESKAPE pathogens.
Research Interests
I am interested in Staphylococcus aureus biology, antibiotic resistance in ESKAPE pathogens, and environmental stress responses, with focus on microbial genetics, bioinformatics, and high throughput methods. I enjoy unraveling the mechanisms behind bacterial infections, and work towards developing innovative strategies alleviating the burden of antibiotic resistant bacterial infections.
Teaching Interests
I have great enthusiasm in guiding new researchers, supervising students, and teaching the future generations in science.I have studied and done extensive research in the field of Microbiology and enjoy teaching all levels of students in Microbiology.During my PhD, I have had the amazing opportunity to teach two years in a row (2018 and 2019) at the Advanced Bacterial Genetics course in Cold Spring Harbor Laboratory, NY, USA.To date, I have supervised 10 final-year BSc Microbiology students, 3 third-year BSc summer students, 1 Erasmus visiting student, 3 Masters of Research students, and 3 PhD students (2 as a primary supervisor, 1 as a co-supervisor).
Related documents
Education/Academic qualification
BSc, MRes, PhD
Accepting PhD Students
- Accepting PhD Students
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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How can we escape the ESKAPEs: Antimicrobial resistance mechanisms and what lies ahead?
Kelly, J. B., Nolan, A. C. & Zeden, M. S., Jun 2024, In: PLoS Pathogens. 20, 6 June, e1012270.Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review
Open Access17 Citations (Scopus) -
Metabolic reprogramming and altered cell envelope characteristics in a pentose phosphate pathway mutant increases MRSA resistance to β-lactam antibiotics
Zeden, M. S., Gallagher, L. A., Bueno, E., Nolan, A. C., Ahn, J., Shinde, D., Razvi, F., Sladek, M., Burke, Ó., O’Neill, E., Fey, P. D., Cava, F., Thomas, V. C. & O’Gara, J. P., 1 Jul 2023, In: PLoS Pathogens. 19, 7 July, e1011536.Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review
Open Access21 Citations (Scopus) -
Purine Nucleosides Interfere with c-di-AMP Levels and Act as Adjuvants To Re-Sensitize MRSA To β-Lactam Antibiotics
Nolan, A. C., Zeden, M. S., Kviatkovski, I., Campbell, C., Urwin, L., Corrigan, R. M., Gründling, A. & O'Gara, J. P., Jan 2023, In: mBio. 14, 1Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review
Open Access40 Citations (Scopus) -
Cyclic di-adenosine monophosphate (c-di-AMP) is required for osmotic regulation in Staphylococcus aureus but dispensable for viability in anaerobic conditions
Zeden, M. S., Schuster, C. F., Bowman, L., Zhong, Q., Williams, H. D. & Gründling, A., 2 Mar 2018, In: Journal of Biological Chemistry. 293, 9, p. 3180-3200 21 p.Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review
Open Access78 Citations (Scopus) -
Identification of the main glutamine and glutamate transporters in Staphylococcus aureus and their impact on c-di-AMP production
Zeden, M. S., Kviatkovski, I., Schuster, C. F., Thomas, V. C., Fey, P. D. & Gründling, A., 1 Jun 2020, In: Molecular Microbiology. 113, 6, p. 1085-1100 16 p.Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review
Open Access34 Citations (Scopus)
Activities
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Aaron Nolan
Zeden, M. (Co-Supervisor)
2 Sep 2013 → 2024Activity: Other › Current Postgraduates (Research) Supervised
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Jessica Kelly
Zeden, M. (Primary Supervisor)
1 Oct 2023 → 30 Sep 2027Activity: Other › Current Postgraduates (Research) Supervised
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Sarah Byrne
Zeden, M. (Primary Supervisor)
1 Sep 2025 → 31 Aug 2029Activity: Other › Current Postgraduates (Research) Supervised
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Brian Oghene
Zeden, M. (Primary Supervisor)
1 Jun 2025 → 31 May 2027Activity: Other › Current Postgraduates (Research) Supervised
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Microbiology Society Annual Meeting in Ireland 2026
Zeden, M. (Conference Organising Committee Member)
3 Nov 2026 → 4 Nov 2026Activity: Participating in or organising an event › Organising a conference, workshop, ...
Prizes
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Outstanding Early Career Microbiologist Award by Federation of European Microbiological Societies (FEMS)
Zeden, M. (Recipient), 14 Jul 2025
Prize
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Deploying PURIne adjuvants to improve the Fight against StaphYlococcus aureus AMR infections (PURIFY AMR)
Zeden, M. (Recipient), Nov 2024
Prize: Honorary award
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Health Research Board CES-2023-003 Conference and Event Sponsorship
Zeden, M. (Recipient), Jun 2023
Prize: Honorary award
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Health Research Board SS-2022-074 Summer Student Grant
Zeden, M. (Recipient), Apr 2022
Prize: Honorary award