Personal profile
Biography
I studied chemistry at the University of Padova (Italy) where I received the MChem Degree in Inorganic and Physical Chemistry in 2000 and, subsequently, the PhD in Chemical Sciences in 2004. After one year of postdoctoral research at the same university, I took up a two-year Marie Curie Intra-European postdoctoral fellowship and, afterwards, a Körber Foundation postdoctoral fellowship at the University of Edinburgh (UK).I returned to Italy in late 2007 and, after a short period as Senior Researcher, in April 2008 I was appointed Assistant Professor of Inorganic Chemistry at the Department of Chemical Sciences of the University of Padova.In February 2013, I was appointed Lecturer in Inorganic Chemistry at the School of Biological and Chemical Sciences (formerly School of Chemistry) of the University of Galway (Formerly NUI Galway).My research interests are within the field of bioinorganic and medicinal inorganic chemistry, with a focus on the interaction between metal complexes and biologically-relevant macromolecules in order to develop new potential anticancer and antiviral agents.Specifically, my professional experience includes the synthesis of coordination compounds (in particular Au, Pt, Pd, lanthanides derivatives) and the use of spectroscopic techniques (mainly mono- and multidimensional NMR, FT-IR and UV-Vis spectroscopy) to characterize the novel metal complexes and study their properties and reactivity under physiological-like conditions.My current research focuses on the design of: (i) metal-based anticancer and imaging agents targeting specific biomarkers up-regulated in tumor cells for the targeted chemotherapy and diagnosis, and (ii) metal-glycoconjugates as antiviral agents against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). I am coauthor of 44 papers published in international peer-reviewed journals (cit. metrics 2002-2023: times cited 3,389, h -index 27, average I.F. 4.371), 3 book chapters, 2 patents and 115 scientific contributions presented at national and international conferences, including 33 oralinvitedkeynote presentations. To date, I have supervised to completion 24 undergraduate, 3 Erasmus+, 2 MSc and 4 PhD students. My research group is currently comprised of 1 masters and 2 PhD students. I am member of the Editorial Board of Recent Patents on Anti-Cancer Drug Discovery (Bentham Science Publishers), Molecules (MDPI) and Frontiers in Chemistry - Inorganic Chemistry (Frontiers Media),and I act regularly as a reviewer for journals published by the major scientific publishing houses.I am member of the Society of Biological Inorganic Chemistry and the Royal Society of Chemistry (MRSC). I am also member of the Standing Committee of the Irish Biological Inorganic Chemistry Society (President since January 2024) and member of the Royal Society of Chemistry - RePublic - No restriction of Ireland Local Section (Secretary since 2020). ORCID ID: 0000-0002-8420-8364 (a target=_blank rel=nofollow href=http:orcid.org0000-0002-8420-8364http:orcid.org0000-0002-8420-8364 ) Scopus ID: 6506737613 (a target=_blank rel=nofollow href=https:www.scopus.comauthiddetail.uri?authorId=6506737613https:www.scopus.comauthiddetail.uri?authorId=6506737613 )
Research Interests
My research interests are within the field of bioinorganic and medicinal inorganic chemistry, with a focus on the interaction between metal complexes and biologically-relevant macromolecules in order to develop new potential anticancer and antiviral agents.Specifically, my professional experience includes the synthesis of coordination compounds (in particular Au, Pt, Pd, lanthanides derivatives) and the use of spectroscopic techniques (mainly mono- and multidimensional NMR, FT-IR and UV-Vis spectroscopy) to characterize the novel metal complexes and study their properties and reactivity under physiological-like conditions.My current research focuses on the design of: (i) metal-based anticancer and imaging agents targeting specific biomarkers up-regulated in tumor cells for the targeted chemotherapy and diagnosis, and (ii) metal-glycoconjugates as antiviral agents against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2).I am coauthor of 44 papers published in international peer-reviewed journals (cit. metrics 2002-2023: times cited 3,389,h -index 27, average I.F. 4.371), 3 book chapters, 2 patents and 115 scientific contributions presented at national and international conferences, including 33 oralinvitedkeynote presentations.Past projects:Sn(IV)-, Pt(II)-, Pd(II)- and Au(IIII)-dithiocarbamato derivatives of amino acids as anticancer agents (1998-2003, University of Padova) Catalytic activity of di-Rh(II) complexes (2003-2004, University of Padova) Photoactivatable Pt(IV)-diazido complexes as potential anticancer agents in Photodynamic therapy (PDT) (2005-2007, University of Edinburgh) Photoactivation of Pt(IV) anticancer agents by means of photonic crystal fibers (2007, University of Edinburgh) Au(III)-dithiocarbamato peptidomimetics for the targeted anticancer chemotherapy (2008-2013, University of Padova) Ongoing projects:Glycosylated metal complexes for the targeted cancer chemotherapy Metal-glycoconjugate inhibitors of SARS-CoV-2 Vitamin B12 as a carrier for the targeted delivery of fluorescent metal-based theranostic agents Vitamin B12-lanthanide conjugates for tumor-imaging applications
Teaching Interests
I teach chemistry-related subjects across the whole undergraduate programme (from 1st to 4th year), as well as at postgraduate level.My topics range from foundation chemistry (BSc (Undenominated), BSc Biopharmaceutical Chemistry) to advanced inorganic and analytical chemistry (BSc Chemistry, BSc Medicinal Chemistry, BSc Biopharmaceutical Chemistry, Structured PhD Chemistry) within a number of modules, including lectures, tutorials and practicals.I currently coordinate one 1st year Module ( CH101 - Chemistry ) and two 3rd year Modules ( CH307 - Inorganic Chemistry and CH334 - Experimental Chemistry II (Inorganic Practicals) ).
Education/Academic qualification
MSc, PhD
External positions
Lecturer (Below the Bar) in Inorganic Chemistry, National University of Ireland Galway (Ireland)
1 Feb 2013 → 31 Aug 2021
Accepting PhD Students
- Accepting PhD Students
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Fluorescent Vitamin B12–Platinum(II) Derivatives as Potential Metallotheranostic Agents for the Treatment and Imaging of Tumors
Mehder, R., de la Torre-Rubio, E., de la Cueva-Alique, I., O’Malley, C., Pérez-Redondo, A., Gude, L., Royo, E. & Ronconi, L., Mar 2024, In: Inorganics. 12, 3, 91.Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review
Open Access7 Citations (Scopus) -
Gold: not just jewelry...
Brescia, F. & Ronconi, L., 1 Apr 2023, In: Future Medicinal Chemistry. 15, 8, p. 647-650 4 p.Research output: Contribution to a Journal (Peer & Non Peer) › Review article › peer-review
3 Citations (Scopus) -
Synthesis, Characterisation, and in vitro Cytotoxic Activity of Dithiocarbamato Glycoconjugate Half-Sandwich Ruthenium and Osmium Complexes
Soldevila-Barreda, J. J., Pettenuzzo, A., Azmanova, M., Rafols, L., Attia, A. A. A., Lupan, A., Ronconi, L., Barry, N. P. E. & Pitto-Barry, A., Aug 2023, In: Helvetica Chimica Acta. 106, 8, e202300064.Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review
Open Access3 Citations (Scopus) -
Metallodrugs as Anticancer Chemotherapeutics and Diagnostic Agents: A Critical Patent Review (2010-2020)
Fotopoulou, E., Titilas, I. & Ronconi, L., Feb 2022, In: Recent Patents on Anti-Cancer Drug Discovery. 17, 1, p. 42-54 13 p.Research output: Contribution to a Journal (Peer & Non Peer) › Review article › peer-review
18 Citations (Scopus) -
Design, physico-chemical characterization andin vitrobiological activity of organogold(iii) glycoconjugates
Pettenuzzo, A., Vezzù, K., Di Paolo, M. L., Fotopoulou, E., Marchiò, L., Via, L. D. & Ronconi, L., 7 Jul 2021, In: Dalton Transactions. 50, 25, p. 8963-8979 17 p.Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review
9 Citations (Scopus)
Activities
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Sebastian Klosowski
Ronconi, L. (Primary Supervisor)
2024 → …Activity: Other › Current Postgraduates (Research) Supervised
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International Symposium on Bioorganometallic Chemistry 2023 - ISBOMC23
Ronconi, L. (Other)
18 Sep 2023 → 21 Sep 2023Activity: Talk or presentation (Unpublished) › Invited Talk
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16th International Symposium on Applied Bioinorganic Chemistry - ISABC16
Ronconi, L. (Other)
11 Jun 2023 → 14 Jun 2023Activity: Talk or presentation (Unpublished) › Oral Presentation
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Ioannis Titilas University of Galway
Ronconi, L. (Primary Supervisor)
2023 → 2024Activity: Other › Postgraduates Supervised
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School of Biological and Chemical Sciences Student Recruitment, Public Engagement and Internationalization Committee(Internal) (External organisation)
Ronconi, L. (Member)
1 Sep 2022 → …Activity: Membership › Membership of committee
Prizes
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Award for the Best Multidisciplinary Project ¿SFP - Science For Patients¿
Ronconi, L. (Recipient), 2005
Prize: Honorary award
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Award for the Best Ph.D. Thesis in Inorganic Chemistry
Ronconi, L. (Recipient), 2004
Prize: Honorary award
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Nomination for a Research Supervisor Award (President¿s Awards for Research Excellence)
Ronconi, L. (Recipient), 2019
Prize: Honorary award
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Special Prize in the section Application-Oriented Scientific Projects
Ronconi, L. (Recipient), 2006
Prize: Honorary award