Research output per year
Research output per year
Accepting PhD Students
PhD projects
My research interests are focused exclusively on inflammatory bowel diseases, which comprise two main diseases: ulcerative colitis and Crohns disease. Research in my group addresses the following questions:
1. What causes inflammatory bowel disease patients to get colon cancer more commonly than others?
2. How can we individualize treatments for inflammatory bowel disease patients so that they receive the optimum drug at the right dose for them?
3. Is it possible to deliver therapeutically active drugs directly to diseased tissues, to avoid systemic exposure to the drugs and minimize toxicity.
These research questions are addressed in a research group that includes scientists, doctors and nurses and is based at the Lambe Institute for Translational Research at University Hospital Galway.
Prof. Egan graduated from UCG in 1990 (M.B., B.Ch., B.A.O.), and completed internship, house officer and registrar training, based at University College Hospital Galway. He received Membership of RCPI in 1992, and Masters in Medical Science from UCG in 1994. From 1994 to 1999, at the Mayo Clinic in Minnesota he completed further training in Internal Medicine, Clinical Pharmacology amp; Gastroenterology, receiving American Board certification in those 3 disciplines. NUI Galway conferred an MD in 1999. Prof. Egan then undertook post-doctoral training from 2000 to 2002, in the Laboratory of Mucosal Immunology at the University of California, San Diego, before returning to the Mayo Clinic to take up a consultancy in Gastroenterology, with joint appointment in the Department of Molecular Pharmacology and Experimental Therapeutics. His research focuses on molecular characterization of signaling pathways involved in intestinal epithelial cell stress, death and malignant transformation, and optimization of personalized approaches to biological therapy in inflammatory bowel diseases. In 2005, Prof. Egan joined NUI Galway and the Health Service Executive Western Region as Professor of Clinical PharmacologyConsultant Clinical Pharmacologist and Head of the Department of Pharmacology amp; Therapeutics, a position he took up in August 2005. Prof. Egan has served as Interim Director of the HRB Clinical Research facility Galway, as Vice-Dean of Research at the College of Medicine Nursing and Health Sciences at NUI Galway, and as Head of the discipline of Pharmacology and Therapeutics. He is a past-President of the Irish Society of Gastroenterology. He was associate editor at Gut, and has been editor-in-chief of the Journal of Crohns and Colitis since 2014.
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
MB BCH BAO MRCPI MD
Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review
Research output: Contribution to a Journal (Peer & Non Peer) › Article
Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review
Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review
Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review
Egan, L. J. (Co-Supervisor)
Activity: Other › Current Postgraduates (Research) Supervised