Dr Karl McCullagh is a lecturer in Department of Physiology and associated with the Regenerative Medicine Institute at NUIG. He has extensive international experience working in North America, Italy and UK, on cellular mechanisms regulating muscle adaptation to innervation, injury and neuromuscular disease. His research group is now exploiting this to further understand basic mechanisms and develop therapeutic interventions for neuromuscular disease including Duchenne Muscular Dystrophy (DMD), using viral and non-viral methods. We are currently interested in genetically modulating and characterizing the effects of neuronal nitric oxide synthase, rectifying calcium dysregulation, and the microvasculature in mouse models of muscle disease including muscular dystrophy and muscle atrophy. He currently teaches and supervises students at undergraduate and postgraduate level on human physiology, and cell and gene therapy.

Muscle biology and plasticityNeuromuscular diseasesMuscular DystrophyGene therapyAdeno-associated virus gene delivery in vivoElectrogene transfer

Skeletal muscle physiologyMolecular Physiology of MuscleCardiovascular PhysiologyGene and cell therapyMolecular BiologyExercise Physiology