Personal profile
Biography
José C. Casas-Martínez is a postdoctoral researcher in Physiology at the University of Galway with a BSc in Biochemistry from the University of Córdoba and a PhD in Molecular Physiology from the University of Galway, with over five years of research experience in redox biology, ageing, and cellular stress responses. His research sits at the interface between fundamental molecular mechanisms and translational medicine, with a particular focus on mitochondria–endoplasmic reticulum (ER) communication, redox signalling, and stress adaptation in ageing and disease.
He completed his doctoral training at the University of Galway, where his work elucidated how adaptive ER stress and redox regulation shape mitochondrial remodelling, longevity, and cellular resilience through mitochondria–ER contact sites (MERCS). His research has resulted in multiple peer-reviewed publications in high-impact journals, including Cell Death & Differentiation, Cellular and Molecular Life Sciences, Redox Biology, and Molecular Metabolism.
Currently, his postdoctoral research focuses on the development of novel TRPA1-targeting therapeutics derived from marine compounds for the treatment of knee osteoarthritis, funded through the Disruptive Technologies Innovation Fund. He has also contributed to academic–industry collaborations aimed at developing innovative medical devices for vascular disease. Alongside his research, he is actively involved in undergraduate and postgraduate teaching within the Department of Physiology.
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Research output
- 12 Article
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Adaptive ER stress promotes mitochondrial remodelling and longevity through PERK-dependent MERCS assembly
Casas-Martinez, J. C., Xia, Q., Li, P., Borja-Gonzalez, M., Miranda-Vizuete, A., McDermott, E., Dockery, P., Quinlan, L. R., Goljanek-Whysall, K., Samali, A. & McDonagh, B., 1 Nov 2025, In: Cell Death & Differentiation.Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review
3 Citations (Scopus) -
Exercise Related microRNAs in C. elegans Regulate Calcium Homeostasis and Mitochondrial Dynamics: Conserved pathways, Divergent mircoRNAs
Xia, Q., Tang, J., Casas-Martinez, J. C., Li, P., Quinlan, L. R., Goljanek-Whysall, K. & McDonagh, B., 2025, In: bioRxiv. p. 2025-05 2019 p.Research output: Contribution to a Journal (Peer & Non Peer) › Article
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MIR-199 regulates neuromuscular homeostasis during ageing: PP IIB05
Sannicandro, A. J., Casas-Martinez, J. C., Outeirino, L. R., Pollock, N., McDonagh, B. & Goljanek-Whysall, K., 2025, In: Free Radical Biology And Medicine. 233, p. S73Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review
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Mitochondrial redox homeostasis links organellar stress surveillance to germline and somatic integrity in Caenorhabditis elegans
Valenzuela-Villatoro, M., de la Cruz-Ruiz, P., Guerrero-Gómez, D., Gómez-Orte, E., Schiavi, A., Maglioni, S., Montero, M., Fonteriz, R. I., Casas-Martinez, J. C., Briand, N. E., Xu, J., Rodriguez-Palero, M. J., Artal-Sanz, M., Olek, K., Polaczyk, J., Turek, M., Pokrzywa, W., Xu, S., Irazoqui, J. E. & McDonagh, B. & 5 others, , 2025, In: bioRxiv.Research output: Contribution to a Journal (Peer & Non Peer) › Article
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PERK orchestrates MERCS formation and mitochondrial remodelling promoting physiological adaptations during adaptive UPR signalling
Casas-Martinez, J. C., Xia, Q., Li, P., Borja-Gonzalez, M., Miranda-Vizuete, A., McDermott, E., Dockery, P., Quinlan, L. R., Goljanek-Whysall, K. & Samali, A., 2025, In: bioRxiv. p. 2025-01 2023 p.Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review