Personal profile
Biography
Affiliation: Associate Professor in Biochemistry, School of biological and Chemical Sciences, University of Galway, Director Blood Cancer Network Ireland, Director Blood Cancer Biobank Ireland, Principal investigator Cancer Niche Laboratory. Career information Prof. Szegezdi received her PhD in medical science in 2000 studying cell death signalling at the University of Debrecen, Hungary. She then joined the Cell Stress and Apoptosis Research laboratory led by Prof. Afshin Samali at the National University of Ireland, Galway (now University of Galway) in 2001 to study stress-induced cell death in heart and pancreatic cells. In 2010 she established her own research group as a Science Foundation Ireland Starting Investigator (SIRG) and an Irish Cancer Society Research Fellow focusing on how the tissues surrounding cancer cells protect the tumour from chemotherapeutics. She took up a university lecturer position in the Discipline of Biochemistry, University of Galway in 2011. In 2017, she received a Research Lectureship position in Cancer Biology. She is an associate professor in Biochemsitry since 2021. She directs Blood Cancer Network Ireland, co-PI in the Centre for Research Training in Genomics Data Science and co-ordinates the H2020-funded INTEGRATE programme within the Genomics CRT. She is also co-PI in Precision Oncology Ireland and Genome of Ireland.
Research Interests
Research in Dr Szegezdis laboratory focuses on death receptor signal transduction and how death receptor signalling shapes the interaction between the tumour and its microenvironment. In this research, she co-ordinated the H2020-RISE research consortium, DISCOVER and co-PI in the follow-on Horizon Europe project, CHIRON.
The second research area of her laboratory is blood caner research, especially acute myeloid leukemia and multiple myeloma and the mechanism of drug resistance mediated by the bone marrow stroma, where these leukemia cells reside. In this research, she has established and leads a national biobank collecting blood cancer patient samples.
Related documents
Education/Academic qualification
M.Sc., Ph.D.
External positions
Associate Professor in Biochemistry, University of Galway
1 May 2022 → …
Keywords
- RC0254 Neoplasms. Tumors. Oncology (including Cancer)
- Acute myeloid leukaemia
- Multiple myeloma
- RM Therapeutics. Pharmacology
- Cell death signalling
- Death receptor signalling
- tumour microenvironment
- single cell transcriptomics
- Natural killer cell
- cellular immunotherapy
Accepting PhD Students
- Accepting PhD Students
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Disrupting membranes, controlling cell fate: the role of pore-forming proteins in cell death and therapy
Iranpour, S., Arif, M. & Szegezdi, E., 21 Jul 2025, In: Apoptosis.Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review
2 Citations (Scopus) -
Protocol for isolation and expansion of natural killer cells from human peripheral blood scalable for clinical applications.
Kundu, S., Durkan, L., O'Dwyer, M. & Szegezdi, E., 26 Feb 2025, In: Biology Methods & Protocols.Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review
4 Citations (Scopus) -
Blood Cancer Network Ireland (BCNI) and National Cancer Registry Ireland (NCRI) collaboration: challenges and utility of an Enhanced Blood Cancer Outcomes Registry (EBCOR) pilot.
Millar, S. R., MB, M., Mykytiv, V., McMorrow, R., Donnelly, C., O'Leary, E., Orfali, N., Murphy, P., PV, B., Quinn, J., O'Gorman, P., MF, R., Clifford, R., EE, H., O'Shea, D., Gilligan, O., Krawczyk, J., o'dwyer, M., Szegezdi, E. & MR, C., 20 Jul 2024, In: Irish Journal Of Medical Science.Research output: Contribution to a Journal (Peer & Non Peer) › Article
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COMBINING SKY92 GENE EXPRESSION PROFILING AND IGH CLONALITY TO EVALUATE GENETIC RISK IN IRISH MULTIPLE MYELOMA PATIENTS
McAvera, R., Drozdz, I., Black, H., Cichocka, T., Szegezdi, E., Quinn, J., Murphy, P., Thornton, P., Perera, M. R., Clifford, R., Keane, N., Mykytiv, V., Elhassadi, E., Cummins, R., O’Dwyer, M. & Glavey, S., 9 May 2023, In: HemaSphere.Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review
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TRAIL promotes the polarization of human macrophages toward a proinflammatory M1 phenotype and is associated with increased survival in cancer patients with high tumor macrophage content
Gunalp, S., Helvacı, D. G., Oner, A., Bursalı, A., Conforte, A., Güner, H., Karakülah, G., Szegezdi, E. & Sag, D., 18 Aug 2023Research output: Other contribution (Published) › Other contribution › peer-review
Activities
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Soumyadipta Kundu
Szegezdi, E. (Primary Supervisor)
2024 → …Activity: Other › Current Postgraduates (Research) Supervised
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Council of the Irish Association of Cancer Research (IACR)(External) (External organisation)
Szegezdi, E. (Member)
1 Apr 2016 → …Activity: Membership › Membership of committee
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Euroscientist (External organisation)
Szegezdi, E. (Member)
1 Jan 2016 → …Activity: Membership › Membership of board
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NUIG Explore Projects: Mini-Med School: Semin
Szegezdi, E. (Other)
1 Nov 2015 → …Activity: Other › Community Engagement/Outreach
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Curriculum Review Commitee for Medical Programme(Internal) (External organisation)
Szegezdi, E. (Member)
1 Sep 2015 → …Activity: Membership › Membership of committee
Prizes
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Irish Cancer Society: Researcher of the Year - finalist
SZEGEZDI, E. E. (Recipient), Mar 2013
Prize: Honorary award
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Irish Cancer Society Research Fellowship - Uncoupling of death receptor-induced nuclear factor kappa B activation from apoptosis.
SZEGEZDI, E. E. (Recipient), Dec 2009
Prize: Honorary award
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President's award-Early stage researcher of the year, NUIG
SZEGEZDI, E. E. (Recipient), Apr 2016
Prize: Honorary award