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Accepting PhD Students

PhD projects

One area of research in my group is death receptor signalling. We study the mechanism of signal transduction in order to understand the driving forces of cancer progression and identify targets for therapy. Based on this information we are developing novel therapeutics that can block pro-survival signalling and thus channel signal transduction towards apoptosis.<br/>My laboratory also studies drug resistance and immune suppression mechanisms in blood cancers. Projects investigate the molecular mechanisms driving immune cell suppression in acute myeloid leukaemia and multiple myeloma with the aim to develop novel cellular immunotherapies insensitive to the suppressive pressure of the tumour microenvironment.

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Personal profile

Biography

Affiliation: Associate Professor in Biochemistry, School of biological and Chemical Sciences, University of Galway, Director Blood Cancer Network Ireland, Director Blood Cancer Biobank Ireland, Principal investigator Cancer Niche Laboratory. Career information Prof. Szegezdi received her PhD in medical science in 2000 studying cell death signalling at the University of Debrecen, Hungary. She then joined the Cell Stress and Apoptosis Research laboratory led by Prof. Afshin Samali at the National University of Ireland, Galway (now University of Galway) in 2001 to study stress-induced cell death in heart and pancreatic cells. In 2010 she established her own research group as a Science Foundation Ireland Starting Investigator (SIRG) and an Irish Cancer Society Research Fellow focusing on how the tissues surrounding cancer cells protect the tumour from chemotherapeutics. She took up a university lecturer position in the Discipline of Biochemistry, University of Galway in 2011. In 2017, she received a Research Lectureship position in Cancer Biology. She is an associate professor in Biochemsitry since 2021. She directs Blood Cancer Network Ireland, co-PI in the Centre for Research Training in Genomics Data Science and co-ordinates the H2020-funded INTEGRATE programme within the Genomics CRT. She is also co-PI in Precision Oncology Ireland and Genome of Ireland.

Research Interests

Research in Dr Szegezdis laboratory focuses on death receptor signal transduction and how death receptor signalling shapes the interaction between the tumour and its microenvironment. In this research, she co-ordinated the H2020-RISE research consortium, DISCOVER and co-PI in the follow-on Horizon Europe project, CHIRON.

The second research area of her laboratory is blood caner research, especially acute myeloid leukemia and multiple myeloma and the mechanism of drug resistance mediated by the bone marrow stroma, where these leukemia cells reside. In this research, she has established and leads a national biobank collecting blood cancer patient samples.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Related documents

Education/Academic qualification

M.Sc., Ph.D.

External positions

Associate Professor in Biochemistry, University of Galway

1 May 2022 → …

Keywords

  • RC0254 Neoplasms. Tumors. Oncology (including Cancer)
  • Acute myeloid leukaemia
  • Multiple myeloma
  • RM Therapeutics. Pharmacology
  • Cell death signalling
  • Death receptor signalling
  • tumour microenvironment
  • single cell transcriptomics
  • Natural killer cell
  • cellular immunotherapy

Accepting PhD Students

  • Accepting PhD Students

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