Cynthia Coleman currently leads a research program 1) investigating the aetiology of diabetes-induced osteopathy; 2) applying adult human marrow-derived mesenchymal stem cells to repair diabetic long bone fractures; 3) identifying the impact of gender on mesenchymal stem cell capacity and 4) investigating the efficacy of coral as a biocompatible bone graph substitute. These investigations are conducted in collaboration with 10+ domestic and international academic and industrial partners, a clinical team at Galway University Hospital and the patient advocacy group Diabetes Ireland. This program has resulted in establishing a new in vivo model of fracture repair at NUIG and the creation of a highly sensitive high-throughput, regulatory body approved methodology to detect the biodistribution of therapeutic progenitor cells. This assay was employed in regulatory submissions in support of clinical trials in wound repair (Endura CT#2015-005580-16) and critical limb ischemia (Endura CT#2013-003447-37).

Diabetes Induced OsteopathyBone Fracture RepairCartilage RepairSkeletal DevelopmentJoint Development Patient Perceptions of Diabetes-Induced OsteopathyImpact of Diabetes on the Outcome of Fragility Fracture Procedures in Irish PatientsCoral as a Bone Substitute

Cellular manufacturingMSC therapySupervising dissertationsAnatomy of bone or cartilageOrthopaedic tissue regeneration