Personal profile
Biography
BIOGRAPHY:
2019-present: Personal Professor of Microbiology, University of Galway, IRELAND.
2014-2019: SeniorLecturer, Microbiology, NUI Galway, IRELAND.
2009-2014: Vice dean for Internationalisation,Collegeof Science, NUI Galway, IRELAND.
2002-2009: Lecturer, Microbiology, NUI Galway, IRELAND.
2000-2002: University Lecturer, University of Aberdeen, SCOTLAND.
1997-2000: ACT(R) Post Doctoral Fellow, University of Aberdeen, SCOTLAND.
1994-1997: Post Doctoral Researcher, Colworth Laboratory, Unilever Plc, ENGLAND.
1990-1994: PhD, University of Dundee (Biochemistry), SCOTLAND.
1986-1990: BSc, Microbiology, University College Cork, IRELAND .
Research Interests
RESEARCH INTERESTS:
Bacterial food-borne pathogens; Listeria monocytogenes; Escherichia coli
Molecular responses to stress
Osmoregulation
Acid stress responses
Sigma factors span
Mechanisms of environmental persistence
Transcriptional responses to environmental stimuli
SYNOPSIS OF ACTIVITY:
The Bacterial Stress Response Group was established in 2000 in the University of Aberdeen and then relocated to NUI Galway in 2002. Research activity within the group centres on an interest in the mechanisms that food-borne bacterial pathogens use to respond and adapt to environmental perturbations. Research projects have focussed on important bacterial pathogens including Salmonella Typhimurium, Escherichia coli and Listeria monocytogenes, all of which cause significant food-borne infections in humans. This research is essential to develop a more complete understanding of how bacterial cells grow and persist in the environment. An understanding of how these pathogens adapt to their environment will also be central to any strategy aimed at curbing their growth both within the host and within the food-chain. Several projects focus on understanding the molecular responses to stress in the human pathogen Listeria monocytogenes, including its responses to oxygen depletion, acidic conditions, increased osmolarity, and light. We collabaorate with researchers throughout Ireland, in the UK and accross Europe. Most recently we lead a MSCA ITN project with 13 PhD students called PATHSENSE, which examined molecular mechansisms of stress sensing in bacteria. Currently research in the group is funded by Research Ireland and the Department of Agriculture, Food and the Marine.
Education/Academic qualification
BSC PHD
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 12 Responsible Consumption and Production
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SDG 14 Life Below Water
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Collaborations and top research areas from the last five years
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A low acriflavine dose strongly potentiates the antimicrobial effect of blue light on Staphylococcus aureus
Allen, R., Somorin, Y., Slemon, M., Zekaite, E., Haugh, C., Hobbs, C., Zeden, M. S., O'Gara, J. P. & O'Byrne, C., 1 Aug 2025, In: Journal of Photochemistry and Photobiology. 28, 100264.Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review
Open Access -
A single point mutation in the Listeria monocytogenes ribosomal gene rpsU enables SigB activation independently of the stressosome and the anti-sigma factor antagonist RsbV
O'Byrne, C., 1 Jan 2024, In: International Journal Of Food Microbiology. 15Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review
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Methods for studying microbial acid stress responses: From molecules to populations
Atasoy, M., Bartkova, S., Çetecioǧlu-Gürol, Z., P Mira, N., O'Byrne, C., Perez-Rodríguez, F., Possas, A., Scheler, O., Sedláková-Kaduková, J., Sinčák, M., Steiger, M., Ziv, C. & Lund, P. A., 1 Sep 2024, In: FEMS Microbiology Reviews. 48, 5, fuae015.Research output: Contribution to a Journal (Peer & Non Peer) › Review article › peer-review
Open Access6 Citations (Scopus) -
The impact of different acidic conditions and food substrates on Listeria monocytogenes biofilms development and removal using nanoencapsulated carvacrol
Yammine, J., Doulgeraki, A. I., O'Byrne, C. P., Gharsallaoui, A., Chihib, N. E. & Karam, L., 2 May 2024, In: International Journal of Food Microbiology. 416, 110676.Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review
Open Access5 Citations (Scopus) -
A novel RofA-family transcriptional regulator, GadR, controls the development of acid resistance in Listeria monocytogenes
Wu, J., McAuliffe, O. & O'Byrne, C. P., Dec 2023, In: mBio. 14, 6Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review
Open Access8 Citations (Scopus)
Activities
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Chuhan Wang
O'Byrne, C. (Primary Supervisor)
2024 → …Activity: Other › Current Postgraduates (Research) Supervised
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Yubin Xue
O'Byrne, C. (Primary Supervisor)
2024 → …Activity: Other › Current Postgraduates (Research) Supervised
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Rachel Allen
O'Byrne, C. (Primary Supervisor)
2024 → …Activity: Other › Current Postgraduates (Research) Supervised
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Internationalisation Committee(Internal) (External organisation)
O'Byrne, C. (Member)
25 Oct 2010 → …Activity: Membership › Membership of committee
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PG Diploma in Academic Practice Higher Education: PG Diploma in Academic Practice
O'Byrne, C. (Participant)
2010 → …Activity: Other › Education