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Bacterial food-borne pathogens have sophisticated systems that allow them to sense and adapt to rapidly changing environments (e.g., the transition from food to host). Research in the lab focuses on both the sensory mechanisms and the adaptive systems in two model bacterial pathogens, Listeria monocytogenes and Escherichia coli. Genetic and molecular biology approaches are applied to understand how these pathogens achieve efficient adaptation, with the ultimate goal of preventing and treating food-borne infections.

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Personal profile

Biography

BIOGRAPHY:

2019-present: Personal Professor of Microbiology, University of Galway, IRELAND.
2014-2019: SeniorLecturer, Microbiology, NUI Galway, IRELAND.
2009-2014: Vice dean for Internationalisation,Collegeof Science, NUI Galway, IRELAND.
2002-2009: Lecturer, Microbiology, NUI Galway, IRELAND.
2000-2002: University Lecturer, University of Aberdeen, SCOTLAND.
1997-2000: ACT(R) Post Doctoral Fellow, University of Aberdeen, SCOTLAND.
1994-1997: Post Doctoral Researcher, Colworth Laboratory, Unilever Plc, ENGLAND.
1990-1994: PhD, University of Dundee (Biochemistry), SCOTLAND.
1986-1990: BSc, Microbiology, University College Cork, IRELAND .

Research Interests

RESEARCH INTERESTS:

Bacterial food-borne pathogens; Listeria monocytogenes; Escherichia coli
Molecular responses to stress 
Osmoregulation
Acid stress responses
Sigma factors span
Mechanisms of environmental persistence
Transcriptional responses to environmental stimuli

SYNOPSIS OF ACTIVITY:

The Bacterial Stress Response Group was established in 2000 in the University of Aberdeen and then relocated to NUI Galway in 2002. Research activity within the group centres on an interest in the mechanisms that food-borne bacterial pathogens use to respond and adapt to environmental perturbations. Research projects have focussed on important bacterial pathogens including Salmonella Typhimurium, Escherichia coli and Listeria monocytogenes, all of which cause significant food-borne infections in humans. This research is essential to develop a more complete understanding of how bacterial cells grow and persist in the environment. An understanding of how these pathogens adapt to their environment will also be central to any strategy aimed at curbing their growth both within the host and within the food-chain. Several projects focus on understanding the molecular responses to stress in the human pathogen Listeria monocytogenes, including its responses to oxygen depletion, acidic conditions, increased osmolarity, and light. We collabaorate with researchers throughout Ireland, in the UK and accross Europe. Most recently we lead a MSCA ITN project with 13 PhD students called PATHSENSE, which examined molecular mechansisms of stress sensing in bacteria. Currently research in the group is funded by Research Ireland and the Department of Agriculture, Food and the Marine.   

Education/Academic qualification

BSC PHD

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being
  2. SDG 12 - Responsible Consumption and Production
    SDG 12 Responsible Consumption and Production
  3. SDG 14 - Life Below Water
    SDG 14 Life Below Water

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