Ananya Gupta

DR

Accepting PhD Students

PhD projects

My Research is particularly aligned with the Universitys research priority themes of cancer treatment, exercise based rehabilitation and biomedical devices.

My Research is also translational, multidisciplinary and collaborative.

Current research projects -
Detection and monitoring of chemotherapy induced Neutropenia in cancer patients using a near patient hand held biomedical device
Implementing a community based program in aerobic exercise and resistance training to improve recovery following cancer treatment
Identification of sports specific physiologic predictors of performance
Role of unfolded signalling pathway in inducing tumour angiogenesis and how it contributes to cancer progression.
Biomarkers of well-being in chronic disease
Molecular mechanisms by which changes in miRNA expression can promote tumorigenesis

Research Interests:
My current research focuses on understanding the toxic effects of cancer chemotherapy, specifically diagnosis and management of chemotherapy induced pan-cytopenia. I have received intramural funding from the School of Medicine and from my Discipline to establish my research. My research has led to the identification of a novel approach and development of a device to monitor chemotherapy induced cytopenia (anaemia and neutropenia) in a near patient setting. This is supported by IDF filed (TECH-2016-040) with TTO-NUI Galway. We have established Proof of Concept using a lab based device. We are able to accurately predict the onset of cytopenia in cancer patients receiving chemotherapy. Based on our preliminary results I have secured funding from Enterprise Ireland (CF-2018-1041-P 600,000 for 2 years) for further development and commercialisation of the device. Two postdoctoral researchers have been recruited to this project to take on the role of Technical lead and commercial specialist. The team is currently engaged in further development and commercialisation of this platform technology for non-invasive analysis of blood cells. Once the miniaturised hand held device is optimised and validated we will conduct a randomised control trial to establish the efficacy of the technology. I have established successful research collaborations with researchers in NUI Galway, across Ireland and abroad to establish my research program.

My research interests also include the application of exercise as therapy for the rehabilitation on cancer patients. In collaboration with Oncology nurses UHG, I have established a Community based rehabilitation program studying the effects of a combined aerobic and resistance exercise intervention in improving cardio-respiratory fitness, reduce fatigue and increase muscle strength, balance, mobility in cancer survivors. CAN-REACT is a community-based survivorship program that involves Public - No restriction and patient in research with an aim to modify existing treatment practices to improve patient outcome and quality of life. The study aims to develop a multidisciplinary intervention in cancer rehabilitation consisting of an individualised, adaptive, exercise program, complemented by appropriate nutrition advice and psycho-social support based on patients needs. This intervention is currently being implemented in a pilot study. Its effectiveness towards improving health and quality of life (QOL) in cancer survivors will be evaluated using appropriate outcome measures. Patients opinion on post-treatment needs will be used to develop printed and web-based resources to inform and enable patients to make their own post-treatment service choices. We are also looking at the application of specific exercise interventions in reducing lymphedema and improving mobility and range of motion in these patients.

Calculated based on number of publications stored in Pure and citations from PlumX

Personal profile

Biography

Education 1992- 1995 Bachelor of Science (B. Sc) in Physiology , First class (Hons) Presidency College, Calcutta University, India 1995- 1997 Master of Science (M. Sc) in Biophysics and Molecular Biology (With Subjects including: Molecular Biology, Biochemistry, Microbiology, Immunology, Biophysics, Biostatistics and Genetics). Calcutta University, India 1998-2005 Ph.D in Life Sciences (Host-Pathogen Interaction and Immunology) Thesis Title: Identification and characterization of different cell death pathways in Leishmania Donovani . Centre for Cellular and Molecular Biology, Hyderabad. Jawaharlal Nehru University, New Delhi, India 2016-2018 Teaching Qualification ( Centre for Excellence in Learning and Teaching (CELT) NUI Galway) Postgraduate Certificate in Teaching and Learning in Higher Education Postgraduate Diploma in Academic Practice Current Position Lecturer (Above the Bar) in Discipline of Physiology (January 2016-Present)Academic Director for MSc in Exercise Physiology and its Application in Therapy

Research Interests

Research Interests:Molecular mechanisms in Cancer progression miRNAs as biomarkers in Cancer prognosis and response to therapy Management and prevention of chemotherapy induced toxicity in Cancer treatment Exercise as Therapy and its Application in Cancer rehabilitation Exercise interventions in training and sports performance My Research is particularly aligned with the Universitys research priority themes of cancer treatment, stem cell derived therapeutics and biomedical devices . My Research is also translational, multidisciplinary and collaborative. Current research projects -Isolation, Expansionand Differentiation of UCB derived HSC into functional Neutrophils for transfusion Detection and monitoring of chemotherapy induced Neutropenia in cancer patients using a near patient hand held biomedical device Implementing a community based program in aerobic exercise and resistance training to improve recovery following cancer treatment Identification of sports specific physiologic predictors of performance Role of unfolded signallingpathway in inducing tumour angiogenesis and how it contributes to cancer progression. Molecular mechanisms by which altered miRNA expression promote tumorigenesis

Teaching Interests

My Teaching philosophy I believe my role, as teacher, is to bring to students the same interest that I feel for my subject. If this is accomplished then each individual student can achieve to the best of their capability. To achieve this, my first goal is to engage students by presenting the appropriate material for each topic in an interesting and enjoyable lesson, my second is to ensure that students understand the topic being taught, and third is to encourage students to appreciate the inherent connections amongst various topics being taught and lastly to continuously assess level of student understanding. I use different methods of teaching and assessment depending on the resources available, the time available and the number and background of students being taught. To make each particular lesson interesting and topical, I use common biological examples, including recent examples from my own research experiences or colleagues work, published literature or from well-known processes or diseases. I provide extra reading and audio-visual material to support what is taught in class. I also try to finish up a topic with a tutorial or problem solving session, where I can gauge the level of comprehension and interest. In order to develop and improve my teaching, I review all the material that I teach regularly. As a teacher I have a responsibility towards students to convey the appropriate knowledge, in an organized manner, in a stimulating environment; to clearly explain what is expected and accurately assess achievements. I use learning outcomes to clearly state what it is that a student will be expected to demonstrate on completion of a particular topic, this not only reassures the student, it helps them learn more effectively. When aligned with teachinglearning activities and assessment methods this provides a transparent, logical framework for defining what needs to be learned, how it will be taught and how it will be assessed. In addition to helping students to learn and appreciate the subject, I feel that we have an obligation to help them with respect to their futures. Many students are not aware of the career options available to them. I like to inform the students about the subject choices and career paths that are open to them, and how best to embark on such paths.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 2 - Zero Hunger
  • SDG 3 - Good Health and Well-being
  • SDG 4 - Quality Education
  • SDG 16 - Peace, Justice and Strong Institutions

Education/Academic qualification

Ph.D

External positions

Lecturer (above the bar) , NUI Galway

7 Jan 2016 → …

Accepting PhD Students

  • Accepting PhD Students

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    Gupta, A. (Primary Supervisor)

    2024

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  • Wen Liu

    Gupta, A. (Co-Supervisor)

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    Activity: OtherCurrent Postgraduates (Research) Supervised

  • Kulsoom Ghias

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    2024

    Activity: OtherCurrent Postgraduates (Research) Supervised

  • Conor Hussey

    Gupta, A. (Primary Supervisor)

    2024

    Activity: OtherCurrent Postgraduates (Research) Supervised

  • Ruth Molloy

    Gupta, A. (Primary Supervisor)

    2024

    Activity: OtherCurrent Postgraduates (Research) Supervised