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Adrienne Gorman

PROF

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PhD projects

The endoplasmic reticulum is responsible for the folding and post-translational modification of secreted and membrane proteins. The accumulation of misfolded or unfolded proteins in the ER induces a state known as ER stress. This leads to activation of a coordinated stress response pathway called the unfolded protein response (UPR). It involves activation of three stress sensors: PERK, IRE1 and ATF6. We are interested in IRE1 signalling, including XBP1 splicing and RIDD, the development of small molecule inhibitors of IRE1 signalling. We use cell and molecular biology as well as bioinformatics approaches to study this.

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Personal profile

Biography

Education and qualificationsBA(Mod) Biochemistry Trinity College DublinPhD Biochemistry Trinity College DublinAppointmentsPersonal Professor, Biochemistry, NUI Galway, 2019-presentSenior Lecturer, Biochemistry, NUI Galway, 2017-2019Vice-Dean for Research in College of Science, 2013-2018Lecturer in Biochemistry, NUI Galway, 2000-2017Post-doctoral research fellow, Karolinska Institutet, Stockholm SwedenPost-doctoral researcher, University College Cork, IrelandMarie CuriePost-doctoral research fellow,University of St Andrews, ScotlandResearch InterestsCell stress response pathways; Cell stress and cell death; Cell survival mechanisms;Endoplasmic reticulum stress; Unfolded protein response; IRE1; Cancer; Triple negative breast cancer

Research Interests

Unfolded protein responseIRE1Cell stress response pathwaysBreast cancer, TNBCEndoplasmic reticulum stress

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 7 - Affordable and Clean Energy

Education/Academic qualification

BA (MOD) Biochemistry, PhD Biochemistry

Accepting PhD Students

  • Accepting PhD Students

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  • 2 Oral Presentation
  • 1 Participating in a conference, workshop, ...
  • 1 Current Postgraduates (Research) Supervised