This report sets out possibilities for greater economic exchange between the west of Ireland, focussing in particular on counties Galway and Mayo, and regions of the United Kingdom. Mayo is relatively strong in pharmaceuticals and life sciences while Galway has particular strengths in medtech with smaller cluster in IT and the creative industries. A review of recent research on industrial clusters in the UK reveals sixteen regions of the UK with similar or overlapping industry sector profiles to Galway and Mayo in the west of Ireland.